Detailed information of TA system TA205105

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2754922..2755547
• Replicon: chromosome
• Accession: NZ_CP076264
• Organism: Escherichia coli strain NADC1036

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: A7A17_RS13565
• Protein ID: WP_000911330.1
• Coordinates: 2754922..2755320 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U9XQV3
• Locus tag: A7A17_RS13570
• Protein ID: WP_000450524.1
• Coordinates: 2755320..2755547 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7A17_RS13545 (2750800)	2750800..2751000	+	201	WP_000383836.1	YpfN family protein	-
A7A17_RS13550 (2751110)	2751110..2751808	-	699	WP_000679823.1	esterase	-
A7A17_RS13555 (2751882)	2751882..2753897	-	2016	WP_000829329.1	tRNA cytosine(34) acetyltransferase TmcA	-
A7A17_RS13560 (2753912)	2753912..2754775	-	864	WP_001267508.1	neutral zinc metallopeptidase	-
A7A17_RS13565 (2754922)	2754922..2755320	-	399	WP_000911330.1	type II toxin-antitoxin system VapC family toxin	Toxin
A7A17_RS13570 (2755320)	2755320..2755547	-	228	WP_000450524.1	toxin-antitoxin system antitoxin VapB	Antitoxin
A7A17_RS13575 (2755701)	2755701..2756414	-	714	WP_001295467.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
A7A17_RS13580 (2756627)	2756627..2757661	-	1035	WP_001358397.1	outer membrane protein assembly factor BamC	-
A7A17_RS13585 (2757678)	2757678..2758556	-	879	WP_001295469.1	4-hydroxy-tetrahydrodipicolinate synthase	-
A7A17_RS13590 (2758702)	2758702..2759274	+	573	WP_000176191.1	glycine cleavage system transcriptional repressor	-
A7A17_RS13595 (2759274)	2759274..2759744	+	471	WP_001068682.1	thioredoxin-dependent thiol peroxidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-52)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14894.25 Da
• Isoelectric Point: 9.2216

>T205105 WP_000911330.1 NZ_CP076264:c2755320-2754922 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Nucleotide

• Length: 399 bp

>T205105 NZ_CP101379:2465027-2465311 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8498.61 Da
• Isoelectric Point: 4.3867

>AT205105 WP_000450524.1 NZ_CP076264:c2755547-2755320 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Nucleotide

• Length: 228 bp

>AT205105 NZ_CP101379:2464789-2465037 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A829CM33