Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/AbrB(antitoxin) |
| Location | 698399..699045 | Replicon | chromosome |
| Accession | NC_002945 | ||
| Organism | Mycobacterium bovis AF2122/97 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TQ88 |
| Locus tag | BQ2027_RS03125 | Protein ID | WP_003403137.1 |
| Coordinates | 698399..698812 (-) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TQ89 |
| Locus tag | BQ2027_RS03130 | Protein ID | WP_003403139.1 |
| Coordinates | 698809..699045 (-) | Length | 79 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BQ2027_RS03105 (BQ2027_MB0610) | 694482..696032 | + | 1551 | WP_003403119.1 | MlaD family protein | - |
| BQ2027_RS03110 (BQ2027_MB0611C) | 696084..696476 | - | 393 | WP_003403122.1 | type II toxin-antitoxin system toxin ribonuclease C4 | - |
| BQ2027_RS03115 (BQ2027_MB0612C) | 696473..696730 | - | 258 | WP_003403125.1 | type II toxin-antitoxin system antitoxin VapB4 | - |
| BQ2027_RS03120 (BQ2027_MB0613C) | 696913..698148 | - | 1236 | WP_003403128.1 | ATP-binding protein | - |
| BQ2027_RS03125 (BQ2027_MB0614C) | 698399..698812 | - | 414 | WP_003403137.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| BQ2027_RS03130 (BQ2027_MB0615C) | 698809..699045 | - | 237 | WP_003403139.1 | type II toxin-antitoxin system antitoxin VapB27 | Antitoxin |
| BQ2027_RS03135 (BQ2027_MB0616C) | 699149..699655 | - | 507 | WP_003900973.1 | two component system sensor kinase HK1 | - |
| BQ2027_RS03140 (BQ2027_MB0617C) | 699769..700299 | - | 531 | WP_003917320.1 | two component system sensor kinase HK2 | - |
| BQ2027_RS03145 (BQ2027_MB0618C) | 700283..700978 | - | 696 | WP_197044064.1 | two-component system response regulator TcrA | - |
| BQ2027_RS03150 (BQ2027_MB0619) | 701101..701412 | + | 312 | WP_010950421.1 | hypothetical protein | - |
| BQ2027_RS03155 (BQ2027_MB0620) | 701484..702434 | + | 951 | WP_003907436.1 | DUF1259 domain-containing protein | - |
| BQ2027_RS03160 (BQ2027_MB0621) | 702675..703259 | + | 585 | WP_003403171.1 | IS607-like element IS1536 family transposase | - |
| BQ2027_RS03165 (BQ2027_MB0622) | 703261..703971 | + | 711 | Protein_634 | IS607 family element RNA-guided endonuclease TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 14786.14 Da Isoelectric Point: 8.1405
>T20510 WP_003403137.1 NC_002945:c698812-698399 [Mycobacterium tuberculosis variant bovis AF2122/97]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA
Download Length: 414 bp
>T20510 NC_002945:c698812-698399 [Mycobacterium tuberculosis variant bovis AF2122/97]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8212.41 Da Isoelectric Point: 5.0351
>AT20510 WP_003403139.1 NC_002945:c699045-698809 [Mycobacterium tuberculosis variant bovis AF2122/97]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK
Download Length: 237 bp
>AT20510 NC_002945:c699045-698809 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|