Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1774824..1775350 | Replicon | chromosome |
| Accession | NZ_CP076264 | ||
| Organism | Escherichia coli strain NADC1036 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | A7A17_RS08670 | Protein ID | WP_000323025.1 |
| Coordinates | 1774824..1775111 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | A7A17_RS08675 | Protein ID | WP_000534858.1 |
| Coordinates | 1775111..1775350 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A17_RS08620 (1769848) | 1769848..1770063 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| A7A17_RS08625 (1770283) | 1770283..1770453 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| A7A17_RS08630 (1770817) | 1770817..1771032 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| A7A17_RS08635 (1771333) | 1771333..1771545 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| A7A17_RS08640 (1771600) | 1771600..1771689 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| A7A17_RS08645 (1771967) | 1771967..1772719 | - | 753 | WP_001047135.1 | antitermination protein | - |
| A7A17_RS08650 (1772733) | 1772733..1773782 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| A7A17_RS08655 (1773784) | 1773784..1774062 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| A7A17_RS08660 (1774129) | 1774129..1774380 | - | 252 | WP_000980994.1 | protein Rem | - |
| A7A17_RS08665 (1774597) | 1774597..1774752 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| A7A17_RS08670 (1774824) | 1774824..1775111 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| A7A17_RS08675 (1775111) | 1775111..1775350 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| A7A17_RS08680 (1775375) | 1775375..1775680 | + | 306 | WP_001326990.1 | protein YdfV | - |
| A7A17_RS08685 (1775883) | 1775883..1776215 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| A7A17_RS08690 (1776652) | 1776652..1776801 | - | 150 | WP_011443592.1 | protein YdfW | - |
| A7A17_RS08695 (1776922) | 1776922..1777584 | - | 663 | Protein_1707 | ISNCY family transposase | - |
| A7A17_RS08700 (1777622) | 1777622..1777993 | - | 372 | WP_244570023.1 | helix-turn-helix domain-containing protein | - |
| A7A17_RS08705 (1778762) | 1778762..1779049 | - | 288 | Protein_1709 | hypothetical protein | - |
| A7A17_RS08710 (1779527) | 1779527..1780016 | - | 490 | Protein_1710 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1739460..1789699 | 50239 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T205095 WP_000323025.1 NZ_CP076264:c1775111-1774824 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T205095 NZ_CP101376:c4803227-4802916 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT205095 WP_000534858.1 NZ_CP076264:c1775350-1775111 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT205095 NZ_CP101376:c4802915-4802625 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|