Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 551177..551795 Replicon chromosome
Accession NZ_CP076264
Organism Escherichia coli strain NADC1036

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag A7A17_RS02690 Protein ID WP_001291435.1
Coordinates 551177..551395 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag A7A17_RS02695 Protein ID WP_000344800.1
Coordinates 551421..551795 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A17_RS02655 (546466) 546466..547038 + 573 WP_000779831.1 YbaY family lipoprotein -
A7A17_RS02660 (547069) 547069..547380 - 312 WP_000409911.1 MGMT family protein -
A7A17_RS02670 (547759) 547759..548112 + 354 WP_000878140.1 DUF1428 domain-containing protein -
A7A17_RS02675 (548154) 548154..549704 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
A7A17_RS02680 (549868) 549868..550338 - 471 WP_000136192.1 YlaC family protein -
A7A17_RS02685 (550454) 550454..551005 - 552 WP_000102568.1 maltose O-acetyltransferase -
A7A17_RS02690 (551177) 551177..551395 - 219 WP_001291435.1 HHA domain-containing protein Toxin
A7A17_RS02695 (551421) 551421..551795 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
A7A17_RS02700 (552341) 552341..555490 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
A7A17_RS02705 (555513) 555513..556706 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T205089 WP_001291435.1 NZ_CP076264:c551395-551177 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T205089 NZ_CP101376:2469721-2470005 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT205089 WP_000344800.1 NZ_CP076264:c551795-551421 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT205089 NZ_CP101376:2469483-2469731 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References