Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2811774..2812399 Replicon chromosome
Accession NZ_CP076262
Organism Escherichia coli strain 0-4

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag A7A18_RS13715 Protein ID WP_000911329.1
Coordinates 2811774..2812172 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag A7A18_RS13720 Protein ID WP_000450524.1
Coordinates 2812172..2812399 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A18_RS13695 (2807652) 2807652..2807852 + 201 WP_000383836.1 YpfN family protein -
A7A18_RS13700 (2807962) 2807962..2808660 - 699 WP_000679823.1 esterase -
A7A18_RS13705 (2808734) 2808734..2810749 - 2016 WP_000829293.1 tRNA cytosine(34) acetyltransferase TmcA -
A7A18_RS13710 (2810764) 2810764..2811627 - 864 WP_001267498.1 neutral zinc metallopeptidase -
A7A18_RS13715 (2811774) 2811774..2812172 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
A7A18_RS13720 (2812172) 2812172..2812399 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
A7A18_RS13725 (2812554) 2812554..2813267 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
A7A18_RS13730 (2813480) 2813480..2814514 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
A7A18_RS13735 (2814531) 2814531..2815409 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
A7A18_RS13740 (2815555) 2815555..2816127 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
A7A18_RS13745 (2816127) 2816127..2816597 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T205073 WP_000911329.1 NZ_CP076262:c2812172-2811774 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T205073 NZ_CP101375:1534505-1534903 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT205073 WP_000450524.1 NZ_CP076262:c2812399-2812172 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT205073 NZ_CP101375:1534278-1534505 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References