Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1826291..1826817 | Replicon | chromosome |
| Accession | NZ_CP076262 | ||
| Organism | Escherichia coli strain 0-4 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | A7A18_RS08860 | Protein ID | WP_000323025.1 |
| Coordinates | 1826291..1826578 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | A7A18_RS08865 | Protein ID | WP_000534858.1 |
| Coordinates | 1826578..1826817 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A18_RS08810 (1821314) | 1821314..1821529 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| A7A18_RS08815 (1821749) | 1821749..1821919 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| A7A18_RS08820 (1822283) | 1822283..1822498 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| A7A18_RS08825 (1822799) | 1822799..1823011 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| A7A18_RS08830 (1823066) | 1823066..1823155 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| A7A18_RS08835 (1823433) | 1823433..1824185 | - | 753 | WP_001047135.1 | antitermination protein | - |
| A7A18_RS08840 (1824199) | 1824199..1825248 | - | 1050 | WP_063087587.1 | DUF968 domain-containing protein | - |
| A7A18_RS08845 (1825250) | 1825250..1825528 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| A7A18_RS08850 (1825595) | 1825595..1825846 | - | 252 | WP_000980994.1 | protein Rem | - |
| A7A18_RS08855 (1826063) | 1826063..1826218 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| A7A18_RS08860 (1826291) | 1826291..1826578 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| A7A18_RS08865 (1826578) | 1826578..1826817 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| A7A18_RS08870 (1826842) | 1826842..1827147 | + | 306 | WP_001326990.1 | protein YdfV | - |
| A7A18_RS08875 (1827350) | 1827350..1827682 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| A7A18_RS08880 (1828119) | 1828119..1828268 | - | 150 | WP_011443592.1 | protein YdfW | - |
| A7A18_RS08885 (1828341) | 1828341..1829438 | - | 1098 | Protein_1743 | ISNCY family transposase | - |
| A7A18_RS08890 (1829493) | 1829493..1829912 | - | 420 | WP_071666191.1 | DUF977 family protein | - |
| A7A18_RS08895 (1829953) | 1829953..1830918 | - | 966 | WP_000054506.1 | hypothetical protein | - |
| A7A18_RS08900 (1830899) | 1830899..1831420 | - | 522 | WP_000705349.1 | toxin YdaT family protein | - |
| A7A18_RS08905 (1831404) | 1831404..1831634 | - | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1790588..1839299 | 48711 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T205063 WP_000323025.1 NZ_CP076262:c1826578-1826291 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T205063 NZ_CP101373:4755768-4756079 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT205063 WP_000534858.1 NZ_CP076262:c1826817-1826578 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT205063 NZ_CP101373:4756076-4756522 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|