Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 84158..84801 | Replicon | plasmid pSA31IncI2 |
Accession | NZ_CP076261 | ||
Organism | Escherichia coli strain WY517-2 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | - |
Locus tag | A7A20_RS24175 | Protein ID | WP_257115067.1 |
Coordinates | 84385..84801 (+) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | A0A627FA37 |
Locus tag | A7A20_RS24170 | Protein ID | WP_001604445.1 |
Coordinates | 84158..84388 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A7A20_RS24140 (79377) | 79377..79793 | - | 417 | WP_001278818.1 | plasmid partitioning/stability family protein | - |
A7A20_RS24145 (79786) | 79786..80766 | - | 981 | WP_000688514.1 | plasmid segregation protein ParM | - |
A7A20_RS24150 (81180) | 81180..81488 | - | 309 | WP_000030199.1 | hypothetical protein | - |
A7A20_RS24155 (81575) | 81575..82219 | - | 645 | WP_001144036.1 | ParA family protein | - |
A7A20_RS24160 (82399) | 82399..83178 | - | 780 | WP_001164201.1 | site-specific integrase | - |
A7A20_RS24165 (83180) | 83180..83593 | - | 414 | WP_000465043.1 | hypothetical protein | - |
A7A20_RS24170 (84158) | 84158..84388 | + | 231 | WP_001604445.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
A7A20_RS24175 (84385) | 84385..84801 | + | 417 | WP_257115067.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
A7A20_RS24180 (84971) | 84971..86371 | - | 1401 | Protein_96 | AAA family ATPase | - |
A7A20_RS24185 (86403) | 86403..87995 | - | 1593 | WP_257115068.1 | IS66 family transposase | - |
A7A20_RS24190 (88026) | 88026..88376 | - | 351 | WP_257115069.1 | IS66 family insertion sequence element accessory protein TnpB | - |
A7A20_RS24195 (88373) | 88373..88807 | - | 435 | WP_188926466.1 | transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | basG | 1..115220 | 115220 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15179.58 Da Isoelectric Point: 6.7132
>T205055 WP_257115067.1 NZ_CP076261:84385-84801 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTKEFERVPDLVLEDWVK
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTKEFERVPDLVLEDWVK
Download Length: 417 bp
>T205055 NZ_CP101373:2161288-2161391 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 77 a.a. Molecular weight: 8736.84 Da Isoelectric Point: 4.4692
>AT205055 WP_001604445.1 NZ_CP076261:84158-84388 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVISDEGRFNL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVISDEGRFNL
Download Length: 231 bp
>AT205055 NZ_CP101373:c2161393-2161248 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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