20505

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0299-vapB/-
Location 364523..365094 Replicon chromosome
Accession NC_002945
Organism Mycobacterium bovis AF2122/97

Toxin (Protein)


Gene name Rv0299 Uniprot ID A0A679LBL4
Locus tag BQ2027_RS01595 Protein ID WP_010950376.1
Coordinates 364523..364825 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag BQ2027_RS01600 Protein ID WP_003401563.1
Coordinates 364873..365094 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ2027_RS01575 (BQ2027_MB0303C) 359947..360750 - 804 WP_003401540.1 Stf0 family sulphotransferase -
BQ2027_RS01580 (BQ2027_MB0304C) 360760..362157 - 1398 WP_003401544.1 sulfatase -
BQ2027_RS01585 (BQ2027_MB0305) 362336..364156 + 1821 WP_003401546.1 PE family protein -
BQ2027_RS01590 (BQ2027_MB0306) 364299..364526 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
BQ2027_RS01595 (BQ2027_MB0307) 364523..364825 + 303 WP_010950376.1 hypothetical protein Toxin
BQ2027_RS01600 (BQ2027_MB0308) 364873..365094 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
BQ2027_RS01605 (BQ2027_MB0309) 365091..365516 + 426 WP_003401566.1 PIN domain nuclease -
BQ2027_RS01610 (BQ2027_MB0310) 365652..366284 + 633 WP_010950377.1 TetR/AcrR family transcriptional regulator -
BQ2027_RS01615 (BQ2027_MB0311) 366281..367189 + 909 WP_003900117.1 protochlorophyllide reductase -
BQ2027_RS20165 367197..367787 - 591 WP_234712434.1 hypothetical protein -
BQ2027_RS20170 367780..367830 - 51 Protein_321 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10469.19 Da        Isoelectric Point: 4.9609

>T20505 WP_010950376.1 NC_002945:364523-364825 [Mycobacterium tuberculosis variant bovis AF2122/97]
MIAPGDIAPRRDNEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T20505 NC_002945:364523-364825 [Mycobacterium tuberculosis variant bovis AF2122/97]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAATGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTTGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT20505 WP_003401563.1 NC_002945:364873-365094 [Mycobacterium tuberculosis variant bovis AF2122/97]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT20505 NC_002945:364873-365094 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A679LBL4

Antitoxin

Source ID Structure
AlphaFold DB A0A829CG48

References