205021

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 584475..585093 Replicon chromosome
Accession NZ_CP076259
Organism Escherichia coli strain WY517-2

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag A7A20_RS02790 Protein ID WP_001291435.1
Coordinates 584475..584693 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag A7A20_RS02795 Protein ID WP_000344800.1
Coordinates 584719..585093 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A20_RS02755 (579764) 579764..580336 + 573 WP_000779831.1 YbaY family lipoprotein -
A7A20_RS02760 (580367) 580367..580678 - 312 WP_000409911.1 MGMT family protein -
A7A20_RS02770 (581057) 581057..581410 + 354 WP_000878140.1 DUF1428 domain-containing protein -
A7A20_RS02775 (581452) 581452..583002 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
A7A20_RS02780 (583166) 583166..583636 - 471 WP_000136192.1 YlaC family protein -
A7A20_RS02785 (583752) 583752..584303 - 552 WP_000102568.1 maltose O-acetyltransferase -
A7A20_RS02790 (584475) 584475..584693 - 219 WP_001291435.1 HHA domain-containing protein Toxin
A7A20_RS02795 (584719) 584719..585093 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
A7A20_RS02800 (585639) 585639..588788 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
A7A20_RS02805 (588811) 588811..590004 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T205021 WP_001291435.1 NZ_CP076259:c584693-584475 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T205021 NZ_CP101369:2116480-2116583 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT205021 WP_000344800.1 NZ_CP076259:c585093-584719 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT205021 NZ_CP101369:c2116585-2116440 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References