Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4508752..4509762 Replicon chromosome
Accession NZ_CP076258
Organism Providencia rettgeri strain W986

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KM147_RS20700 Protein ID WP_232370503.1
Coordinates 4508752..4509465 (-) Length 238 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KM147_RS20705 Protein ID WP_181468903.1
Coordinates 4509505..4509762 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM147_RS20690 (KM147_20690) 4504701..4507748 - 3048 WP_282551101.1 formate dehydrogenase-N subunit alpha -
KM147_RS20695 (KM147_20695) 4507925..4508755 + 831 WP_042846771.1 formate dehydrogenase accessory sulfurtransferase FdhD -
KM147_RS20700 (KM147_20700) 4508752..4509465 - 714 WP_232370503.1 HipA domain-containing protein Toxin
KM147_RS20705 (KM147_20705) 4509505..4509762 - 258 WP_181468903.1 helix-turn-helix domain-containing protein Antitoxin
KM147_RS20710 (KM147_20710) 4509918..4510682 - 765 WP_042846773.1 hypothetical protein -
KM147_RS20715 (KM147_20715) 4510813..4512177 - 1365 WP_042846829.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
KM147_RS20720 (KM147_20720) 4512305..4513954 - 1650 WP_198861035.1 membrane protein insertase YidC -
KM147_RS20725 (KM147_20725) 4513957..4514217 - 261 WP_042846775.1 membrane protein insertion efficiency factor YidD -
KM147_RS20730 (KM147_20730) 4514181..4514540 - 360 WP_072035181.1 ribonuclease P protein component -
KM147_RS20735 (KM147_20735) 4514562..4514705 - 144 WP_042846776.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(4-200)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 238 a.a.        Molecular weight: 27198.26 Da        Isoelectric Point: 8.0790

>T205018 WP_232370503.1 NZ_CP076258:c4509465-4508752 [Providencia rettgeri]
VTLFAQVLGLISLNDVPHSFILNVGEIKALAVERFDRKYSSDSSWIMRLPQEDFCQTLNISPARKYQNHGGPGISEIMNY
LLGSINAEKDRYQFMKSQVLFWLLAATDGHAKNFSLFIEPEGRYQLTPFYDILSMYPSYGGRGINPRDAKLAMGLKGTRE
MKYNIEQIFPRHFFATAKEVGFDRTEMEKILIEFDEQMESVITKVREQLPTNFPKHIADSILSGLHHKAARLKKGWD

Download         Length: 714 bp

>T205018 NZ_CP101369:852586-852999 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
ACATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9627.86 Da        Isoelectric Point: 10.0521

>AT205018 WP_181468903.1 NZ_CP076258:c4509762-4509505 [Providencia rettgeri]
MKVTNTRQLSAYMKDVRETKKLSQSKVASKVGIRQDTVSSFELSPDSTKLETFFKILSALNLELDIKPRNESGSSNSNSG
WKEEW

Download         Length: 258 bp

>AT205018 NZ_CP101369:852339-852605 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTGATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References