Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3094135..3094792 Replicon chromosome
Accession NZ_CP076258
Organism Providencia rettgeri strain W986

Toxin (Protein)


Gene name cptA Uniprot ID A0A1J0E9L4
Locus tag KM147_RS14275 Protein ID WP_042845040.1
Coordinates 3094135..3094545 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1J0E9J6
Locus tag KM147_RS14280 Protein ID WP_042845042.1
Coordinates 3094526..3094792 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM147_RS14255 (KM147_14255) 3090074..3091807 - 1734 WP_129466205.1 single-stranded-DNA-specific exonuclease RecJ -
KM147_RS14260 (KM147_14260) 3091817..3092521 - 705 WP_042845413.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KM147_RS14265 (KM147_14265) 3092543..3093445 - 903 WP_129466206.1 site-specific tyrosine recombinase XerD -
KM147_RS14270 (KM147_14270) 3093563..3094081 + 519 WP_042845038.1 flavodoxin FldB -
KM147_RS14275 (KM147_14275) 3094135..3094545 - 411 WP_042845040.1 protein YgfX Toxin
KM147_RS14280 (KM147_14280) 3094526..3094792 - 267 WP_042845042.1 FAD assembly factor SdhE Antitoxin
KM147_RS14285 (KM147_14285) 3095042..3096031 + 990 WP_198860828.1 tRNA-modifying protein YgfZ -
KM147_RS14290 (KM147_14290) 3096043..3096663 + 621 WP_071548274.1 HD domain-containing protein -
KM147_RS14295 (KM147_14295) 3096824..3097714 + 891 WP_233102462.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15461.25 Da        Isoelectric Point: 10.6538

>T205017 WP_042845040.1 NZ_CP076258:c3094545-3094135 [Providencia rettgeri]
VVLWKSNLSISWKTQFFSTCVHGAVGMFLLVAPWAPAHSMIWLPLLAVVVASWAKSQKNISKIKGVAVLVNGNKVQWKKN
EWNIVKAPWLSRYGILLSLEALQGKQQKIHLWVAKDSVSEESWRNLNQLLLQYPDI

Download         Length: 411 bp

>T205017 NZ_CP101369:335579-335947 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCAGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10619.16 Da        Isoelectric Point: 4.8780

>AT205017 WP_042845042.1 NZ_CP076258:c3094792-3094526 [Providencia rettgeri]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDSLTTNDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMVKLIQEKN
KNRGPVEI

Download         Length: 267 bp

>AT205017 NZ_CP101369:335361-335582 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAGAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0E9L4

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0E9J6

References