Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2194498..2195417 Replicon chromosome
Accession NZ_CP076258
Organism Providencia rettgeri strain W986

Toxin (Protein)


Gene name - Uniprot ID A0A1J0E7D4
Locus tag KM147_RS09975 Protein ID WP_042843809.1
Coordinates 2194498..2194959 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1J0E7A8
Locus tag KM147_RS09980 Protein ID WP_042843808.1
Coordinates 2194956..2195417 (-) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM147_RS09950 (KM147_09950) 2190000..2191460 + 1461 WP_042844339.1 AMP nucleosidase -
KM147_RS09955 (KM147_09955) 2191477..2192010 + 534 WP_233102505.1 GNAT family N-acetyltransferase -
KM147_RS09960 (KM147_09960) 2192067..2192489 + 423 WP_042843814.1 helix-turn-helix domain-containing protein -
KM147_RS09965 (KM147_09965) 2192596..2193555 + 960 WP_166684924.1 acetyl-CoA carboxylase carboxyl transferase subunit alpha -
KM147_RS09970 (KM147_09970) 2193599..2194489 + 891 WP_042843811.1 LysR family transcriptional regulator -
KM147_RS09975 (KM147_09975) 2194498..2194959 - 462 WP_042843809.1 RES domain-containing protein Toxin
KM147_RS09980 (KM147_09980) 2194956..2195417 - 462 WP_042843808.1 DUF2384 domain-containing protein Antitoxin
KM147_RS09985 (KM147_09985) 2195507..2195974 - 468 WP_042843807.1 DUF1456 family protein -
KM147_RS09990 (KM147_09990) 2196160..2196474 - 315 WP_042843806.1 AzlD domain-containing protein -
KM147_RS09995 (KM147_09995) 2196471..2197172 - 702 WP_048607181.1 AzlC family ABC transporter permease -
KM147_RS10000 (KM147_10000) 2197859..2198500 + 642 WP_048607183.1 leucine efflux protein LeuE -
KM147_RS10005 (KM147_10005) 2198560..2199018 - 459 WP_042843802.1 GNAT family N-acetyltransferase -
KM147_RS10010 (KM147_10010) 2199437..2199823 + 387 WP_048607185.1 cytidine deaminase -
KM147_RS10015 (KM147_10015) 2199847..2200311 + 465 WP_198861407.1 NUDIX domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(38-95)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 17499.99 Da        Isoelectric Point: 6.4846

>T205016 WP_042843809.1 NZ_CP076258:c2194959-2194498 [Providencia rettgeri]
MILYRLIKSDFAHDAWSGQGARLYGGRWNHKGTPAIYTSTSISLAALEILVHINQDTVLNHFTLLSIEINDRYVMKLSVE
HLPDDWQRDPAPTSTMDIGTTWLTNQDSLALIVPSCIIPYEYNAIINPMHPQFQKVTQTIKPLDFAFDPRFNR

Download         Length: 462 bp

>T205016 NZ_CP101369:225763-226248 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTTGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATA
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 17086.57 Da        Isoelectric Point: 9.9812

>AT205016 WP_042843808.1 NZ_CP076258:c2195417-2194956 [Providencia rettgeri]
MRNYIPALPTQPTTPPFKPLWRFAGLPAERGIELTHFLRQGLSVTVLDNIQEWSGISKSELLRISGINERNVARRRNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKSMASDWLNHPVKGLGHTRPIELIATESGALEVIDLIGRIEHGVFS

Download         Length: 462 bp

>AT205016 NZ_CP101369:225488-225775 [Salmonella enterica]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATTAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0E7D4

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0E7A8

References