Detailed information of TA system TA205015

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1648826..1649334
• Replicon: chromosome
• Accession: NZ_CP076258
• Organism: Providencia rettgeri strain W986

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: KM147_RS07345
• Protein ID: WP_048606785.1
• Coordinates: 1648826..1649134 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: KM147_RS07350
• Protein ID: WP_233102512.1
• Coordinates: 1649134..1649334 (-)
• Length: 67 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KM147_RS07315 (KM147_07315)	1644718..1645554	+	837	WP_042844279.1	CheR family methyltransferase	-
KM147_RS07320 (KM147_07320)	1645554..1646621	+	1068	WP_042844278.1	chemotaxis response regulator protein-glutamate methylesterase	-
KM147_RS07325 (KM147_07325)	1646661..1647053	+	393	WP_034782834.1	chemotaxis response regulator CheY	-
KM147_RS07330 (KM147_07330)	1647078..1647716	+	639	WP_042844277.1	protein phosphatase CheZ	-
KM147_RS07335 (KM147_07335)	1647933..1648232	+	300	WP_042844276.1	helix-turn-helix transcriptional regulator	-
KM147_RS07340 (KM147_07340)	1648253..1648810	-	558	WP_129465770.1	hypothetical protein	-
KM147_RS07345 (KM147_07345)	1648826..1649134	-	309	WP_048606785.1	CcdB family protein	Toxin
KM147_RS07350 (KM147_07350)	1649134..1649334	-	201	WP_233102512.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
KM147_RS07355 (KM147_07355)	1649539..1650690	+	1152	WP_048606786.1	flagellar biosynthesis protein FlhB	-
KM147_RS07360 (KM147_07360)	1650683..1652782	+	2100	WP_042844272.1	flagellar biosynthesis protein FlhA	-
KM147_RS07365 (KM147_07365)	1653153..1653593	-	441	WP_042844271.1	flagellar export chaperone FlgN	-
KM147_RS07370 (KM147_07370)	1653603..1653905	-	303	WP_042844270.1	flagellar biosynthesis anti-sigma factor FlgM	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (1-66)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11677.74 Da
• Isoelectric Point: 6.4602

>T205015 WP_048606785.1 NZ_CP076258:c1649134-1648826 [Providencia rettgeri]
MQYCLYQNREDTVKHPYLLDIQSNIIDILNTLLVIPLFDSRLVKKPLPTCLNPQLFSNGQVFVLMTHQMACVPHSLLGKE
IVDLNCQQNTIKHAIDLLIDGF

Nucleotide

• Length: 309 bp

>T205015 NZ_CP101369:c87089-86721 [Salmonella enterica]
ATGCAAAACGTTTTATCACTGCCTTCACCGGCAGCGGCCTCGTCACGCCTGTCGCCCGTCGAAGCCTGGCAAAAACTGCT
GTCGTACCTGCTGCAACGCCACTACGGCCTTGAACTTAACGACACGCCATTCTGCGACGATATTGTTATTCAGGAACATA
TCAACGCAGGCGTTGCGCTTGCCGATGCCGTTAACTTTCTGGTGGAAAAGTACGGACTTGTTCGTATCGATCGCAAGGGA
TTTAGCTGGCAGGAACAATCACCCTATCTCCGGGCTGTCGATATTCTGCGGGCGCGGAAAGCAACGGGGTTGTTAACACG
TTGCAAAAAACACAATGGTAATCAGCCTGATGGCAGATTCACTCTATGA

Antitoxin

Protein

• Length: 67 a.a.
• Molecular weight: 7668.77 Da
• Isoelectric Point: 6.2432

>AT205015 WP_233102512.1 NZ_CP076258:c1649334-1649134 [Providencia rettgeri]
ITVAPELCEQAWRAKLNLSAILTCALQAELKRLEAQKWKNENIEGFNQLNRNNEEYGLLSDKYKVF

Nucleotide

• Length: 201 bp

>AT205015 NZ_CP101369:c87433-87104 [Salmonella enterica]
ATGCCCCAAAACCAACCCTCCGCGCCTGTCTGGGGCCTGCGGAGCGATATCACGCCCTCGTTTGGCGCTCGGTTAGTGCA
GGAAGGTTGTCGCCTGCATTTTCTGCCCGACCGCGCCAGCCTTCGCGGTGATTTCACTGCGGAACAACTACACTCGCTGG
ATATCACCTTTCCGCAGTTTGTGAAGCAACTGGAATCGGCGCTGAAAAGCGGGGCGCTCGATCCGCACCAGTCGCGCCGC
TACAGCACCATCCTCAATGGCCTGACCTGCGAAGCCGACACCAACGGTAGTCACGGCTACGTTTACCTCACTATCTACCC
AGCCGAATAA