Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 899492..900138 Replicon chromosome
Accession NZ_CP076258
Organism Providencia rettgeri strain W986

Toxin (Protein)


Gene name Hha Uniprot ID A0A1J0E3F0
Locus tag KM147_RS03885 Protein ID WP_042846891.1
Coordinates 899492..899695 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1J0E3I4
Locus tag KM147_RS03890 Protein ID WP_042846890.1
Coordinates 899770..900138 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM147_RS03860 (KM147_03860) 895571..895909 + 339 WP_042846895.1 P-II family nitrogen regulator -
KM147_RS03865 (KM147_03865) 895959..897203 + 1245 WP_233102508.1 ammonium transporter AmtB -
KM147_RS03870 (KM147_03870) 897344..898210 - 867 WP_042846893.1 acyl-CoA thioesterase II -
KM147_RS03875 (KM147_03875) 898450..898908 + 459 WP_166685880.1 YbaY family lipoprotein -
KM147_RS03885 (KM147_03885) 899492..899695 - 204 WP_042846891.1 HHA domain-containing protein Toxin
KM147_RS03890 (KM147_03890) 899770..900138 - 369 WP_042846890.1 Hha toxicity modulator TomB Antitoxin
KM147_RS03895 (KM147_03895) 900668..902038 - 1371 WP_048608373.1 murein transglycosylase D -
KM147_RS03900 (KM147_03900) 902120..902872 - 753 WP_042846888.1 hydroxyacylglutathione hydrolase -
KM147_RS03905 (KM147_03905) 902906..903640 + 735 WP_042846887.1 methyltransferase domain-containing protein -
KM147_RS03910 (KM147_03910) 903637..904107 - 471 WP_042846886.1 ribonuclease HI -
KM147_RS03915 (KM147_03915) 904162..904923 + 762 WP_042846885.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8087.38 Da        Isoelectric Point: 6.9770

>T205014 WP_042846891.1 NZ_CP076258:c899695-899492 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 204 bp

>T205014 NZ_CP101366:c52723-52442 [Salmonella enterica]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14123.05 Da        Isoelectric Point: 4.3849

>AT205014 WP_042846890.1 NZ_CP076258:c900138-899770 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSAQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWETMNQNLVSVLDDDLKCLTSKT

Download         Length: 369 bp

>AT205014 NZ_CP101366:c52964-52713 [Salmonella enterica]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0E3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0E3I4

References