Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 3600435..3601027 Replicon chromosome
Accession NZ_CP076252
Organism Xanthomonas translucens pv. graminis strain ART-Xtg9

Toxin (Protein)


Gene name PumA Uniprot ID A0A1M4L1P2
Locus tag KM579_RS15990 Protein ID WP_009580424.1
Coordinates 3600435..3600731 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag KM579_RS15995 Protein ID WP_009580422.1
Coordinates 3600734..3601027 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM579_RS15975 (KM579_15860) 3595732..3596895 - 1164 WP_009580518.1 ADP-forming succinate--CoA ligase subunit beta -
KM579_RS15980 (KM579_15865) 3597194..3598807 + 1614 WP_009580428.1 HAMP domain-containing sensor histidine kinase -
KM579_RS15985 (KM579_15870) 3598882..3600270 + 1389 WP_009580426.1 sigma-54 dependent transcriptional regulator -
KM579_RS15990 (KM579_15875) 3600435..3600731 + 297 WP_009580424.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KM579_RS15995 (KM579_15880) 3600734..3601027 + 294 WP_009580422.1 putative addiction module antidote protein Antitoxin
KM579_RS16000 (KM579_15885) 3601055..3602791 - 1737 WP_009580420.1 type IV-A pilus assembly ATPase PilB -
KM579_RS16005 (KM579_15890) 3602998..3603288 + 291 WP_009580418.1 nucleotidyltransferase family protein -
KM579_RS16010 (KM579_15895) 3603285..3603605 + 321 WP_009580416.1 DUF86 domain-containing protein -
KM579_RS16015 3603705..3603956 + 252 WP_009580414.1 transposase -
KM579_RS16020 3603957..3604262 + 306 WP_231103532.1 hypothetical protein -
KM579_RS16025 (KM579_15905) 3604924..3605334 - 411 WP_039955568.1 pilin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(39-91)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11153.73 Da        Isoelectric Point: 10.3355

>T205004 WP_009580424.1 NZ_CP076252:3600435-3600731 [Xanthomonas translucens pv. graminis]
VIELKQTETFRKWRTKLKDERARTAIALRLTRLAYGHAGDTEAVGQGISELRIHHGPGYRVYFQRRGDTIIVLLCGGDKS
SQAKDIKTAKRLADEWSE

Download         Length: 297 bp

>T205004 NZ_CP101365:2064948-2065051 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10376.69 Da        Isoelectric Point: 4.9890

>AT205004 WP_009580422.1 NZ_CP076252:3600734-3601027 [Xanthomonas translucens pv. graminis]
MTENLTTYDPAEDLNSDQAIADFMAGAFATNDTGFIAHALGIVARAKGMTQIARQTGLSREQLYRSFSEDGNPTLRTTLA
VMKALGIELTAKAAVTH

Download         Length: 294 bp

>AT205004 NZ_CP101365:c2065053-2064910 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4L1P2

Antitoxin

Source ID Structure

References