205003

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4309469..4309854 Replicon chromosome
Accession NZ_CP076251
Organism Xanthomonas translucens pv. phlei strain LMG 730

Toxin (Protein)


Gene name EcnB Uniprot ID A0A0K2ZHE5
Locus tag KM547_RS18880 Protein ID WP_003469322.1
Coordinates 4309469..4309603 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID A0A0K2ZNU2
Locus tag KM547_RS18885 Protein ID WP_009574163.1
Coordinates 4309702..4309854 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM547_RS18860 (KM547_18765) 4305796..4306719 - 924 WP_053838561.1 MBL fold metallo-hydrolase -
KM547_RS18865 (KM547_18770) 4306796..4308196 - 1401 WP_053838562.1 tryptophan--tRNA ligase -
KM547_RS18870 (KM547_18775) 4308307..4308984 + 678 WP_237651149.1 hypothetical protein -
KM547_RS18875 (KM547_18780) 4309055..4309270 - 216 WP_009574162.1 CsbD family protein -
KM547_RS18880 (KM547_18785) 4309469..4309603 - 135 WP_003469322.1 entericidin A/B family lipoprotein Toxin
KM547_RS18885 (KM547_18790) 4309702..4309854 - 153 WP_009574163.1 entericidin A/B family lipoprotein Antitoxin
KM547_RS18890 (KM547_18795) 4310000..4310923 - 924 WP_053838580.1 arginase -
KM547_RS18900 (KM547_18805) 4311347..4312189 - 843 WP_053838563.1 SPOR domain-containing protein -
KM547_RS18905 (KM547_18810) 4312199..4312939 - 741 WP_053838564.1 type III pantothenate kinase -
KM547_RS18910 (KM547_18815) 4312936..4313901 - 966 WP_053838565.1 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA -
KM547_RS18915 (KM547_18820) 4314063..4314335 + 273 WP_170867545.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4604.40 Da        Isoelectric Point: 9.2977

>T205003 WP_003469322.1 NZ_CP076251:c4309603-4309469 [Xanthomonas translucens pv. phlei]
MKRTFAWMLLAMFSVGLLSGCNTVAGAGKDVKSAGEKVEDAAKN

Download         Length: 135 bp

>T205003 NZ_CP101365:1946811-1947164 [Salmonella enterica]
GTGTGGACAATTAAAACAACGGATACGTTTGATCGCTGGTTTGCCTCGCTCAACGATACCAACAGGGTCAGCGTGCTTGC
AGCACTGCTGGTCCTGCGAGAAAAGGGGCCGGGTTTGTCCAGACCTTATGCCGATACGGTCAGAGGTTCCCGTTACAGCA
ACATGAAAGAGCTACGTATTCAGAGTCGGGGCGAGCCGATACGGGCGTTTTTCGCTTTTGACCCGACCCGTACCGGCATT
GTGCTTTGTGCCGGAAATAAGGTCGGTAATGAAAAACGTTTTTACGATGAGATGCTCCCTGTTGCTGACAGGGAATTCAC
GAACTGGCTGAACACATTAAAAGAGAAGGAGTAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5393.44 Da        Isoelectric Point: 8.1210

>AT205003 WP_009574163.1 NZ_CP076251:c4309854-4309702 [Xanthomonas translucens pv. phlei]
MKRLFTLMMLTLFCAGMLTGCNTMAGAGKDMQKAGDKVENKADDCKDGKC

Download         Length: 153 bp

>AT205003 NZ_CP101365:1947169-1947471 [Salmonella enterica]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAGAAACCTGAAGTCGTGGCCGAAGCTCAGGCGATGGCGACGGACAT
CCTGCTCAACATTCACCTTGCCGAACTGCGTGAGAAAGTACAGAAAACGCAGGTGGAGATGGCACAGGCGCTGGGCATCA
GGCAACCTACCGTTGCAGGAATGGAAAAACCAGGGCGCGATCTGAAGCTTTCCACTCTCAAACGCTACGTTGAAGCGACA
GGCGGCAAGCTACGTCTTGATGTTGAACTGCCGGATGGTTCTCACTACGGATTTGTACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2ZHE5

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2ZNU2

References