Detailed information of TA system TA205001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1692609..1693174
• Replicon: chromosome
• Accession: NZ_CP076251
• Organism: Xanthomonas translucens pv. phlei strain LMG 730

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KM547_RS07440
• Protein ID: WP_080998920.1
• Coordinates: 1692609..1692929 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0K2ZGI9
• Locus tag: KM547_RS07445
• Protein ID: WP_053834608.1
• Coordinates: 1692917..1693174 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KM547_RS07425 (KM547_07370)	1687775..1688245	+	471	Protein_1453	GFA family protein	-
KM547_RS07430 (KM547_07375)	1688582..1689328	+	747	WP_053837214.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
KM547_RS07435 (KM547_07380)	1689816..1692599	+	2784	WP_237651287.1	ligand-binding sensor domain-containing diguanylate cyclase	-
KM547_RS07440 (KM547_07385)	1692609..1692929	-	321	WP_080998920.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KM547_RS07445 (KM547_07390)	1692917..1693174	-	258	WP_053834608.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KM547_RS07450 (KM547_07395)	1693284..1693910	-	627	WP_144422974.1	hypothetical protein	-
KM547_RS07455 (KM547_07400)	1694212..1694856	-	645	WP_053834609.1	ribonuclease T	-
KM547_RS07460 (KM547_07405)	1695250..1695996	-	747	WP_053837213.1	putative DNA-binding domain-containing protein	-
KM547_RS07465 (KM547_07410)	1695989..1696864	-	876	WP_053837212.1	DUF692 domain-containing protein	-
KM547_RS07470 (KM547_07415)	1696851..1697213	-	363	WP_053837211.1	hypothetical protein	-
KM547_RS07475 (KM547_07420)	1697416..1698126	-	711	WP_053837210.1	phosphate signaling complex protein PhoU	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12015.65 Da
• Isoelectric Point: 7.3589

>T205001 WP_080998920.1 NZ_CP076251:c1692929-1692609 [Xanthomonas translucens pv. phlei]
MAEIVWSEPALADLDAIADYIALESPVAASELVKRSFDHVEQLGEHPDSGSQPQELGRSRYRQRVEPPCRVFYRHDGHTV
FMLQVMRSERLLRKGRLASRAGQAKV

Nucleotide

• Length: 321 bp

>T205001 NZ_CP101365:860582-860980 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9659.17 Da
• Isoelectric Point: 8.7288

>AT205001 WP_053834608.1 NZ_CP076251:c1693174-1692917 [Xanthomonas translucens pv. phlei]
MRTELVTPLKRQATELLADIERDRQPILITQHGLPSAYLVDVETHELMQQRMAVLEGIARGEQAVAEGRVATQAEARKRL
GRWLK

Nucleotide

• Length: 258 bp

>AT205001 NZ_CP101365:860355-860582 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGATGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0K2ZGI9