Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1131349..1131854 Replicon chromosome
Accession NZ_CP076251
Organism Xanthomonas translucens pv. phlei strain LMG 730

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2ZZ27
Locus tag KM547_RS05085 Protein ID WP_053838318.1
Coordinates 1131349..1131606 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID A0A1C3TRJ9
Locus tag KM547_RS05090 Protein ID WP_003468816.1
Coordinates 1131603..1131854 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM547_RS05055 (KM547_05035) 1126601..1127950 + 1350 WP_053838315.1 aminodeoxychorismate synthase component I -
KM547_RS05060 (KM547_05040) 1128020..1129087 + 1068 WP_186008158.1 endolytic transglycosylase MltG -
KM547_RS05065 (KM547_05045) 1129084..1129752 + 669 WP_053838316.1 dTMP kinase -
KM547_RS05070 (KM547_05050) 1129749..1130711 + 963 WP_053838317.1 DNA polymerase III subunit delta' -
KM547_RS05075 (KM547_05055) 1130708..1131061 + 354 WP_003479797.1 PilZ domain-containing protein -
KM547_RS05085 (KM547_05065) 1131349..1131606 - 258 WP_053838318.1 Txe/YoeB family addiction module toxin Toxin
KM547_RS05090 (KM547_05070) 1131603..1131854 - 252 WP_003468816.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KM547_RS05095 (KM547_05075) 1132009..1132773 + 765 WP_053838319.1 endonuclease -
KM547_RS05100 (KM547_05080) 1132770..1133492 - 723 WP_053838320.1 helix-turn-helix transcriptional regulator -
KM547_RS05105 (KM547_05085) 1133614..1134057 + 444 WP_053838321.1 nuclear transport factor 2 family protein -
KM547_RS05110 1134093..1134416 - 324 WP_053838335.1 hypothetical protein -
KM547_RS05115 1134447..1134647 - 201 WP_237651245.1 hypothetical protein -
KM547_RS05120 (KM547_05095) 1135298..1135594 + 297 WP_053838322.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10154.64 Da        Isoelectric Point: 9.3063

>T205000 WP_053838318.1 NZ_CP076251:c1131606-1131349 [Xanthomonas translucens pv. phlei]
VTLQFSDNAWEDYLYWQQTDKKMLKRINDLIKAIQHDPFQGVGKPEPLRHALAGYWSRRINDEHRIVYKVEAGVLLIAQV
RYHYV

Download         Length: 258 bp

>T205000 NZ_CP101365:850874-851287 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9281.56 Da        Isoelectric Point: 5.1186

>AT205000 WP_003468816.1 NZ_CP076251:c1131854-1131603 [Xanthomonas translucens pv. phlei]
MDTITYSAARAALADTMERVVNNHEPVIITRSREQSVVMLSLEDYKAMEETAYLLRSPKSAQRLLESIAQLEAGRGKARD
LAE

Download         Length: 252 bp

>AT205000 NZ_CP101365:850627-850893 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2ZZ27

Antitoxin

Source ID Structure
AlphaFold DB A0A1C3TRJ9

References