Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 2234814..2235478 Replicon chromosome
Accession NC_002944
Organism Mycobacterium avium subsp. paratuberculosis K-10

Toxin (Protein)


Gene name vapC Uniprot ID Q73YC9
Locus tag MAP_RS10300 Protein ID WP_003872398.1
Coordinates 2234814..2235221 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q73YC8
Locus tag MAP_RS10305 Protein ID WP_003872399.1
Coordinates 2235218..2235478 (-) Length 87 a.a.

Genomic Context

MAP_RS10280MAP_RS22690MAP_RS10315MAP_RS10285MAP_RS10290MAP_RS10295MAP_RS10300MAP_RS10305MAP_RS10310MAP_RS10320MAP_RS10325
Location: 2230014..2231183 (1170 bp)
Type: Others
Protein ID: WP_003878212.1
Location: 2233123..2234667 (1545 bp)
Type: Others
Protein ID: WP_010949452.1
Location: 2236277..2237545 (1269 bp)
Type: Others
Protein ID: WP_003872401.1
Location: 2231172..2231702 (531 bp)
Type: Others
Protein ID: WP_003878213.1
Location: 2231823..2232368 (546 bp)
Type: Others
Protein ID: WP_003878214.1
Location: 2232365..2232886 (522 bp)
Type: Others
Protein ID: WP_003878215.1
Location: 2234814..2235221 (408 bp)
Type: Toxin
Protein ID: WP_003872398.1
Location: 2235218..2235478 (261 bp)
Type: Antitoxin
Protein ID: WP_003872399.1
Location: 2235659..2236111 (453 bp)
Type: Others
Protein ID: WP_003872400.1
Location: 2237747..2239204 (1458 bp)
Type: Others
Protein ID: WP_003878220.1
Location: 2239400..2240062 (663 bp)
Type: Others
Protein ID: WP_003872403.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MAP_RS102802230014..2231183+1170WP_003878212.1hypothetical protein-
MAP_RS102852231172..2231702-531WP_003878213.1TetR/AcrR family transcriptional regulator-
MAP_RS102902231823..2232368-546WP_003878214.1carboxymuconolactone decarboxylase family protein-
MAP_RS102952232365..2232886-522WP_003878215.1carboxymuconolactone decarboxylase family protein-
MAP_RS226902233123..2234667+1545WP_010949452.1serine/threonine protein kinase-
MAP_RS103002234814..2235221-408WP_003872398.1type II toxin-antitoxin system VapC family toxinToxin
MAP_RS103052235218..2235478-261WP_003872399.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
MAP_RS103102235659..2236111-453WP_003872400.1VOC family protein-
MAP_RS103152236277..2237545+1269WP_003872401.1cytochrome P450-
MAP_RS103202237747..2239204-1458WP_003878220.1serine/threonine protein kinase-
MAP_RS103252239400..2240062-663WP_003872403.1TetR/AcrR family transcriptional regulator-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14418.47 Da        Isoelectric Point: 4.5642

>T20500 WP_003872398.1 NC_002944:c2235221-2234814 [Mycobacterium avium subsp. paratuberculosis K-10]
MTARPAAGVLDTSVFIASESGRQLDEARIPDEVATTVVTLAELHAGVLAATTSNVRAQRLATLESIADMEMLPVDDDAVR
MWARLRIHLAEAGRRMRANDLWIAAIAASRGLPVVTQDDDFAALDGAANLAIIRV

Download         Length: 408 bp

>T20500 NC_002944:c2235221-2234814 [Mycobacterium avium subsp. paratuberculosis K-10]
ATGACTGCAAGGCCGGCGGCCGGGGTGCTCGACACCTCGGTGTTCATCGCGTCCGAAAGCGGACGGCAGCTGGACGAGGC
GCGTATCCCCGACGAGGTAGCCACCACCGTCGTCACCCTTGCCGAACTTCACGCCGGCGTATTAGCCGCGACGACGTCCA
ACGTTCGGGCGCAACGCCTCGCAACGCTGGAATCGATAGCGGATATGGAAATGCTGCCAGTCGACGACGACGCGGTCCGC
ATGTGGGCAAGGTTGCGGATCCACCTAGCCGAGGCTGGACGGCGGATGCGGGCTAATGATCTGTGGATCGCGGCGATCGC
GGCATCGCGGGGACTGCCCGTTGTCACCCAGGATGACGACTTCGCCGCACTCGACGGCGCGGCGAACCTGGCGATTATTC
GGGTTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9635.01 Da        Isoelectric Point: 11.7137

>AT20500 WP_003872399.1 NC_002944:c2235478-2235218 [Mycobacterium avium subsp. paratuberculosis K-10]
MSEVASRELRNDTAGVLRRVREGEDVTITINGRAVAMLTPLRPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT20500 NC_002944:c2235478-2235218 [Mycobacterium avium subsp. paratuberculosis K-10]
ATGTCTGAAGTGGCGTCTCGCGAGCTGCGCAACGATACGGCGGGGGTACTGCGGCGCGTACGGGAAGGGGAGGACGTCAC
CATCACCATCAACGGCCGAGCCGTCGCGATGCTGACCCCGCTGCGGCCGCAGCGACGGCGGTGGCTGAGCAAGGCGGAGT
TGCTGTCGCGCTTGCGCCGCGCGCAAGCCGATCCCGGGCTACGCCAAGACCTCGCAACCCTTGCAGGCGACACCACTGAG
GACCTCGGTCCGATCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A7L5MIC8

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A7L5MIC5

References