Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/ParD(antitoxin)
Location 1938246..1939244 Replicon chromosome
Accession NC_002944
Organism Mycobacterium avium subsp. paratuberculosis K-10

Toxin (Protein)


Gene name pezT Uniprot ID X7VT18
Locus tag MAP_RS09035 Protein ID WP_003876749.1
Coordinates 1938246..1938824 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID Q73Z26
Locus tag MAP_RS09040 Protein ID WP_003878042.1
Coordinates 1938855..1939244 (-) Length 130 a.a.

Genomic Context

MAP_RS09015MAP_RS09030MAP_RS09060MAP_RS09010MAP_RS09020MAP_RS09025MAP_RS09035MAP_RS09040MAP_RS09045MAP_RS09050MAP_RS09055
Location: 1935339..1935689 (351 bp)
Type: Others
Protein ID: WP_003878038.1
Location: 1937174..1938241 (1068 bp)
Type: Others
Protein ID: WP_010949354.1
Location: 1943429..1944109 (681 bp)
Type: Others
Protein ID: WP_010949357.1
Location: 1933799..1935019 (1221 bp)
Type: Others
Protein ID: WP_010948702.1
Location: 1935703..1936503 (801 bp)
Type: Others
Protein ID: WP_003876746.1
Location: 1936503..1937063 (561 bp)
Type: Others
Protein ID: WP_003878040.1
Location: 1938246..1938824 (579 bp)
Type: Toxin
Protein ID: WP_003876749.1
Location: 1938855..1939244 (390 bp)
Type: Antitoxin
Protein ID: WP_003878042.1
Location: 1939325..1939819 (495 bp)
Type: Others
Protein ID: WP_010949355.1
Location: 1939816..1941813 (1998 bp)
Type: Others
Protein ID: WP_003876752.1
Location: 1941832..1943349 (1518 bp)
Type: Others
Protein ID: WP_015632643.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MAP_RS090101933799..1935019-1221WP_010948702.1IS110 family transposase-
MAP_RS090151935339..1935689+351WP_003878038.1DoxX family protein-
MAP_RS090201935703..1936503-801WP_003876746.1nuclear transport factor 2 family protein-
MAP_RS090251936503..1937063-561WP_003878040.1pyrazinamidase PncA-
MAP_RS090301937174..1938241+1068WP_010949354.1DoxX family membrane protein-
MAP_RS090351938246..1938824-579WP_003876749.1zeta toxin family proteinToxin
MAP_RS090401938855..1939244-390WP_003878042.1hypothetical proteinAntitoxin
MAP_RS090451939325..1939819-495WP_010949355.1gluconokinase-
MAP_RS090501939816..1941813-1998WP_003876752.1phosphotransferase-
MAP_RS090551941832..1943349-1518WP_015632643.1carboxylesterase/lipase family protein-
MAP_RS090601943429..1944109+681WP_010949357.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--1933799..19349981199


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(5-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21034.18 Da        Isoelectric Point: 10.6678

>T20499 WP_003876749.1 NC_002944:c1938824-1938246 [Mycobacterium avium subsp. paratuberculosis K-10]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV

Download         Length: 579 bp

>T20499 NC_002944:c1938824-1938246 [Mycobacterium avium subsp. paratuberculosis K-10]
ATGGAGCGACTCGACGTGGTGGTCGGGCCCAACGGCGCCGGCAAGTCGACGTTCATCGCGTTGACCCTGGCGCCGCTGCT
GCCGGGCAGCGTGGTGGTCAACGCCGACGAGATCGCGCGGCAGCGCTGGCCGCAGGATCCGGCGTCGCACGCCTACGACG
CCGCGAAGGTCGCCGCCGACACCCGGGCGAAGCTGATCGACCTGGGCCGGTCGTTCATCGCCGAGACCGTGTTCTCCCAC
CCGTCCAAGCTGGACCTGCTGCACGCCGCCCGCCGCGCCGGCTTCACCGTCGTGCTGCACGTGCTGCTCATCCCGGAAGA
CCTTGCCGTCGAACGGGTCCGGCACCGCGTGCGGGCCGGCGGCCATGACGTGCCGGAAACCAAGATCCGCGAGCGGCATC
GCCGGTTGTGGACTCCGGTCGCCGAGGCGATGACCCTGGCCGACCTGGCCACCGGCTACGACAACAGCCGGCTGCGCGGG
CCGCGTGTGGTGGCCCGGCTCAGCGGCGGGCTGACGGTCGGTGCCGTCGACTGGCCGGCGTGGGCACCCGAGACCTTGCG
GTCGCGTTGGCCGGTCTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13569.99 Da        Isoelectric Point: 5.6717

>AT20499 WP_003878042.1 NC_002944:c1939244-1938855 [Mycobacterium avium subsp. paratuberculosis K-10]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAEITAEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR

Download         Length: 390 bp

>AT20499 NC_002944:c1939244-1938855 [Mycobacterium avium subsp. paratuberculosis K-10]
ATGGCCGAGGCCGTCGATCGGGTCACCCGGGTCGCGTCCGATCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGTCAGAG
CCGCTCGGCCAAGCAGCAGCTCGACCACTGGGCGCGGGTCGGGCGTGCGGTGTCCAGCCAGCACACCGCGTCCCGGCGGC
GGGTCGAAGCCGCGCTGGCCGGCCGGCTGTCCACCGCCGAAATCACCGCCGAAGAGGGCGTGGTGTTCAACGCCGAGATC
TCGGCGGCCATCGACGAAAGCCTGGCGCGCACCAACTACGGGGCGACGCTGGCCGGGCAGGGTGTCACCACGGTGGCCCT
CAACGACGATGGCGAGATCGTCGAGCACCGGCCCGACGGCACCGCGGTGGTGCTGGCCGGCCGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E2W6B4

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U6EQJ5

References