Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 865233..865886 Replicon chromosome
Accession NC_002944
Organism Mycobacterium avium subsp. paratuberculosis K-10

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MAP_RS04310 Protein ID WP_003872880.1
Coordinates 865425..865886 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID Q742J1
Locus tag MAP_RS04305 Protein ID WP_003872881.1
Coordinates 865233..865421 (+) Length 63 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAP_RS04295 861215..862801 + 1587 WP_003872883.1 serine hydrolase -
MAP_RS04300 862798..865170 + 2373 WP_003872882.1 HAD-IC family P-type ATPase -
MAP_RS04305 865233..865421 + 189 WP_003872881.1 antitoxin Antitoxin
MAP_RS04310 865425..865886 + 462 WP_003872880.1 SRPBCC family protein Toxin
MAP_RS04315 865955..866389 + 435 WP_003877359.1 hypothetical protein -
MAP_RS04320 867385..868968 + 1584 WP_003872878.1 DUF4185 domain-containing protein -
MAP_RS04325 869008..869394 + 387 WP_003872877.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-142)

Antitoxin

(4-51)


Sequences


Toxin        


Download         Length: 154 a.a.        Molecular weight: 16626.19 Da        Isoelectric Point: 9.5654

>T20498 WP_003872880.1 NC_002944:865425-865886 [Mycobacterium avium subsp. paratuberculosis K-10]
VAKLSGSIDVPLPPEVAWQHASDLSRYKEWLTIHRVWRSTLPDQIDKGTVVESIVEVKGMLNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKVQPKADGSVVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFARSDPSTNGHR

Download         Length: 462 bp

>T20498 NC_002944:865425-865886 [Mycobacterium avium subsp. paratuberculosis K-10]
GTGGCCAAGCTTTCCGGATCCATCGATGTTCCGCTGCCCCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGAGTGGCTGACCATTCACCGGGTGTGGCGCAGCACCTTGCCCGACCAGATCGACAAGGGCACCGTCGTCGAGTCGA
TCGTCGAGGTCAAAGGCATGCTCAACCGGATCAAATGGACGGTGGTGCGCTACAAGCCACCGGAGGGGATGACGCTCAAC
GGCGACGGCGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGGTGCAGCCCAAGGCGGACGGTTCCGTCGTCAGCTTCGA
CGTGCACCTCGGCGGTCCGGCGCTGTTCGGGCCCATCGGCATGATCGTCGCGGCCGCGCTGCGCGGCGACATCGACCAGT
CGCTGGAGAACTTCGTCACGGTGTTCGCCCGATCGGATCCGAGCACCAACGGTCATCGCTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6745.42 Da        Isoelectric Point: 4.4865

>AT20498 WP_003872881.1 NC_002944:865233-865421 [Mycobacterium avium subsp. paratuberculosis K-10]
MGFLDKAKDLLSQNADKVEMAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKATGATETGDQQG

Download         Length: 189 bp

>AT20498 NC_002944:865233-865421 [Mycobacterium avium subsp. paratuberculosis K-10]
ATGGGATTCCTGGACAAGGCCAAGGACCTGTTGTCGCAGAACGCCGACAAGGTCGAGATGGCCATCGACAAGGCCGGCGA
GTTCGTCGACGAGAAGACCCAGGGCAAGTACTCCGACACCATCCACCAGGTGCAGGAGCAGGCCAAGAAGGCCACCGGCG
CCACCGAGACCGGCGACCAGCAGGGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E2WC18

References