Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 865233..865886 Replicon chromosome
Accession NC_002944
Organism Mycobacterium avium subsp. paratuberculosis K-10

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MAP_RS04310 Protein ID WP_003872880.1
Coordinates 865425..865886 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID Q742J1
Locus tag MAP_RS04305 Protein ID WP_003872881.1
Coordinates 865233..865421 (+) Length 63 a.a.

Genomic Context

MAP_RS04295MAP_RS04300MAP_RS04305MAP_RS04310MAP_RS04315MAP_RS04320MAP_RS04325
Location: 861215..862801 (1587 bp)
Type: Others
Protein ID: WP_003872883.1
Location: 862798..865170 (2373 bp)
Type: Others
Protein ID: WP_003872882.1
Location: 865233..865421 (189 bp)
Type: Antitoxin
Protein ID: WP_003872881.1
Location: 865425..865886 (462 bp)
Type: Toxin
Protein ID: WP_003872880.1
Location: 865955..866389 (435 bp)
Type: Others
Protein ID: WP_003877359.1
Location: 867385..868968 (1584 bp)
Type: Others
Protein ID: WP_003872878.1
Location: 869008..869394 (387 bp)
Type: Others
Protein ID: WP_003872877.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MAP_RS04295861215..862801+1587WP_003872883.1serine hydrolase-
MAP_RS04300862798..865170+2373WP_003872882.1HAD-IC family P-type ATPase-
MAP_RS04305865233..865421+189WP_003872881.1antitoxinAntitoxin
MAP_RS04310865425..865886+462WP_003872880.1SRPBCC family proteinToxin
MAP_RS04315865955..866389+435WP_003877359.1hypothetical protein-
MAP_RS04320867385..868968+1584WP_003872878.1DUF4185 domain-containing protein-
MAP_RS04325869008..869394+387WP_003872877.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(2-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-51)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16626.19 Da        Isoelectric Point: 9.5654

>T20498 WP_003872880.1 NC_002944:865425-865886 [Mycobacterium avium subsp. paratuberculosis K-10]
VAKLSGSIDVPLPPEVAWQHASDLSRYKEWLTIHRVWRSTLPDQIDKGTVVESIVEVKGMLNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKVQPKADGSVVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFARSDPSTNGHR

Download         Length: 462 bp

>T20498 NC_002944:865425-865886 [Mycobacterium avium subsp. paratuberculosis K-10]
GTGGCCAAGCTTTCCGGATCCATCGATGTTCCGCTGCCCCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGAGTGGCTGACCATTCACCGGGTGTGGCGCAGCACCTTGCCCGACCAGATCGACAAGGGCACCGTCGTCGAGTCGA
TCGTCGAGGTCAAAGGCATGCTCAACCGGATCAAATGGACGGTGGTGCGCTACAAGCCACCGGAGGGGATGACGCTCAAC
GGCGACGGCGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGGTGCAGCCCAAGGCGGACGGTTCCGTCGTCAGCTTCGA
CGTGCACCTCGGCGGTCCGGCGCTGTTCGGGCCCATCGGCATGATCGTCGCGGCCGCGCTGCGCGGCGACATCGACCAGT
CGCTGGAGAACTTCGTCACGGTGTTCGCCCGATCGGATCCGAGCACCAACGGTCATCGCTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6745.42 Da        Isoelectric Point: 4.4865

>AT20498 WP_003872881.1 NC_002944:865233-865421 [Mycobacterium avium subsp. paratuberculosis K-10]
MGFLDKAKDLLSQNADKVEMAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKATGATETGDQQG

Download         Length: 189 bp

>AT20498 NC_002944:865233-865421 [Mycobacterium avium subsp. paratuberculosis K-10]
ATGGGATTCCTGGACAAGGCCAAGGACCTGTTGTCGCAGAACGCCGACAAGGTCGAGATGGCCATCGACAAGGCCGGCGA
GTTCGTCGACGAGAAGACCCAGGGCAAGTACTCCGACACCATCCACCAGGTGCAGGAGCAGGCCAAGAAGGCCACCGGCG
CCACCGAGACCGGCGACCAGCAGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E2WC18

References