Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3481820..3482298 Replicon chromosome
Accession NZ_CP076245
Organism Escherichia coli O157:H7 strain Balcarce_24.2

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag JKN64_RS17920 Protein ID WP_001303876.1
Coordinates 3482011..3482298 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag JKN64_RS17915 Protein ID WP_000536233.1
Coordinates 3481820..3482011 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKN64_RS17880 (3477224) 3477224..3477994 - 771 WP_000450992.1 DUF1627 domain-containing protein -
JKN64_RS17885 (3478016) 3478016..3478762 - 747 WP_000788751.1 ATP-binding protein -
JKN64_RS17890 (3478769) 3478769..3479860 - 1092 WP_001205823.1 hypothetical protein -
JKN64_RS17895 (3479939) 3479939..3480394 + 456 WP_000273724.1 hypothetical protein -
JKN64_RS17900 (3480601) 3480601..3481026 - 426 WP_000693855.1 toxin YdaT family protein -
JKN64_RS17905 (3481010) 3481010..3481282 - 273 WP_000887453.1 YdaS family helix-turn-helix protein -
JKN64_RS17910 (3481391) 3481391..3481792 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
JKN64_RS17915 (3481820) 3481820..3482011 + 192 WP_000536233.1 hypothetical protein Antitoxin
JKN64_RS17920 (3482011) 3482011..3482298 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JKN64_RS17925 (3482576) 3482576..3482731 + 156 WP_000379575.1 DUF1391 family protein -
JKN64_RS27765 (3482733) 3482733..3482861 + 129 WP_000344963.1 protein YdfB -
JKN64_RS17930 (3482873) 3482873..3483262 + 390 WP_000394511.1 hypothetical protein -
JKN64_RS17935 (3483449) 3483449..3483634 - 186 WP_001133046.1 hypothetical protein -
JKN64_RS17940 (3484208) 3484208..3484396 + 189 WP_000413705.1 cell division inhibition protein DicB -
JKN64_RS17945 (3484393) 3484393..3484584 + 192 WP_001098307.1 DUF1482 family protein -
JKN64_RS17950 (3484678) 3484678..3487149 + 2472 WP_000034457.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T204975 WP_001303876.1 NZ_CP076245:3482011-3482298 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T204975 NZ_CP101305:c5000429-5000043 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGGGTCCCCCACGATCCGTCTTGCGTCTTGAATTCCGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT204975 WP_000536233.1 NZ_CP076245:3481820-3482011 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT204975 NZ_CP101305:c5000968-5000459 [Escherichia coli]
ATGGCATATCTGAAATTGATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGCCTTTACTCTATGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGCATTG
GTGACTACTGGTACAACTTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAGTTGAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATT
TGATCTCGCAAACATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References