Detailed information of TA system TA020496

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2710991..2711619
• Replicon: chromosome
• Accession: NC_002939
• Organism: Geobacter sulfurreducens PCA

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q74AB8
• Locus tag: GS_RS12430
• Protein ID: WP_010943110.1
• Coordinates: 2710991..2711392 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q74AB7
• Locus tag: GS_RS12435
• Protein ID: WP_010943111.1
• Coordinates: 2711392..2711619 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GS_RS12405	2706789..2707139	+	351	WP_010943106.1	hypothetical protein	-
GS_RS12410	2707292..2707819	+	528	WP_010943107.1	hypothetical protein	-
GS_RS12415	2707843..2708598	+	756	WP_010943108.1	hypothetical protein	-
GS_RS12420	2708636..2709025	+	390	WP_010943109.1	hypothetical protein	-
GS_RS12425	2709103..2710443	-	1341	WP_164930422.1	group II intron reverse transcriptase/maturase	-
GS_RS12430	2710991..2711392	-	402	WP_010943110.1	type II toxin-antitoxin system VapC family toxin	Toxin
GS_RS12435	2711392..2711619	-	228	WP_010943111.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GS_RS12440	2712203..2715013	+	2811	WP_010943112.1	GPMC system transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14702.12 Da
• Isoelectric Point: 4.8615

>T20496 WP_010943110.1 NC_002939:c2711392-2710991 [Geobacter sulfurreducens PCA]
MKLLLDTNICIYIIKQQPVAVLERFLEYQVGDIGISSITLSELRYGVAKSTHMEKNAKALDEFIIPLELVSYDESAAHVY
GDIRAALEKAGTPIGSMDMLIAAHAVSLGIPLVTNNTREFLRVPSLNIIDWTV

Nucleotide

• Length: 402 bp

>T20496 NC_002939:c2711392-2710991 [Geobacter sulfurreducens PCA]
ATGAAATTGCTTCTCGACACCAATATCTGCATTTACATCATAAAGCAGCAGCCGGTTGCTGTACTTGAGCGTTTCTTAGA
GTACCAGGTTGGCGATATTGGCATTTCATCCATAACTCTCTCGGAATTGCGCTACGGAGTTGCGAAGAGCACCCATATGG
AGAAAAACGCCAAGGCCCTCGACGAATTCATCATTCCTTTGGAATTGGTTTCTTATGATGAATCGGCGGCTCATGTCTAT
GGAGATATTCGAGCAGCTCTTGAAAAAGCTGGTACGCCCATTGGCTCCATGGATATGTTGATTGCCGCTCACGCTGTATC
GTTAGGAATCCCTCTGGTCACTAATAACACCCGCGAGTTTTTACGGGTCCCTTCCCTCAATATCATTGATTGGACGGTTT
AG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8772.02 Da
• Isoelectric Point: 10.5623

>AT20496 WP_010943111.1 NC_002939:c2711619-2711392 [Geobacter sulfurreducens PCA]
MKTAKIFQNGQSQAVRLPKEFRFEDSEVFIKKSGNVVQLIPRSDSWNSLFGSLKKFSRDFMSERIQPELDKRDGF

Nucleotide

• Length: 228 bp

>AT20496 NC_002939:c2711619-2711392 [Geobacter sulfurreducens PCA]
ATGAAAACTGCAAAGATTTTTCAAAATGGACAAAGTCAGGCAGTAAGGCTTCCCAAAGAATTTCGCTTCGAAGACAGCGA
AGTATTCATCAAGAAAAGCGGCAACGTCGTTCAACTGATCCCTCGGAGCGATTCGTGGAATTCCCTCTTCGGCAGTCTCA
AGAAATTCTCCCGCGATTTCATGTCCGAGCGCATACAACCTGAACTGGACAAGCGGGATGGCTTCTGA

Structures

Toxin

• AlphaFold DB: Q74AB8

Antitoxin

• AlphaFold DB: Q74AB7