Detailed information of TA system TA020495

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2673838..2674363
• Replicon: chromosome
• Accession: NC_002939
• Organism: Geobacter sulfurreducens PCA

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q74AD7
• Locus tag: GS_RS12260
• Protein ID: WP_010943076.1
• Coordinates: 2674073..2674363 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q74AD8
• Locus tag: GS_RS12255
• Protein ID: WP_010943075.1
• Coordinates: 2673838..2674083 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GS_RS12235	2669939..2670646	-	708	WP_010943071.1	lipoyl(octanoyl) transferase LipB	-
GS_RS12240	2670676..2671932	-	1257	WP_010943072.1	2-oxo acid dehydrogenase subunit E2	-
GS_RS12245	2671948..2672934	-	987	WP_010943073.1	alpha-ketoacid dehydrogenase subunit beta	-
GS_RS12250	2672975..2673460	-	486	WP_010943074.1	VOC family protein	-
GS_RS12255	2673838..2674083	+	246	WP_010943075.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GS_RS12260	2674073..2674363	+	291	WP_010943076.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GS_RS12265	2674412..2674828	-	417	WP_010943077.1	hypothetical protein	-
GS_RS12270	2674956..2675702	-	747	WP_010943078.1	class I SAM-dependent methyltransferase	-
GS_RS12275	2675927..2676949	-	1023	WP_010943079.1	RelA/SpoT domain-containing protein	-
GS_RS12285	2677706..2678683	-	978	WP_010943082.1	pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-67)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11331.30 Da
• Isoelectric Point: 10.4995

>T20495 WP_010943076.1 NC_002939:2674073-2674363 [Geobacter sulfurreducens PCA]
MSYSLEFKESALKEWKKLDGRIREQFKKKLTERLELPRVEPARLSGMPDCYKIKLKNAGYRLVYQVDDNRIIVTVVAVGK
RENLTVYRAAEKRVKQ

Nucleotide

• Length: 291 bp

>T20495 NC_002939:2674073-2674363 [Geobacter sulfurreducens PCA]
ATGAGCTATAGCCTCGAATTCAAGGAATCCGCCCTGAAGGAGTGGAAAAAACTCGATGGCAGAATCCGTGAACAGTTTAA
GAAGAAGCTTACCGAACGGCTTGAGCTTCCTCGCGTCGAGCCGGCCCGACTCTCCGGCATGCCCGATTGCTACAAAATCA
AGCTGAAGAACGCCGGCTACCGGCTGGTTTACCAGGTTGACGACAACCGCATCATCGTTACTGTCGTGGCTGTCGGAAAA
CGCGAAAACCTTACCGTTTATCGAGCGGCAGAGAAAAGGGTGAAACAGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9193.46 Da
• Isoelectric Point: 4.6631

>AT20495 WP_010943075.1 NC_002939:2673838-2674083 [Geobacter sulfurreducens PCA]
MERLFARASVSISDLKKNPTRIINQSEGEPVAILNHNKPSAYLIPADAFEALMEKLEDYELSQIVKEREHEPSVKVSLDE
L

Nucleotide

• Length: 246 bp

>AT20495 NC_002939:2673838-2674083 [Geobacter sulfurreducens PCA]
ATGGAACGTCTTTTTGCCCGTGCCTCGGTCAGCATAAGTGACCTTAAAAAAAACCCCACCCGAATCATTAATCAGTCCGA
AGGTGAACCTGTGGCAATCCTCAACCACAACAAGCCAAGTGCATACTTAATCCCCGCCGATGCCTTCGAGGCGCTCATGG
AGAAACTGGAGGATTATGAGCTTTCCCAAATTGTGAAGGAACGGGAACACGAGCCGAGTGTCAAGGTCTCCCTCGATGAG
CTATAG

Structures

Toxin

• AlphaFold DB: Q74AD7

Antitoxin

• AlphaFold DB: Q74AD8