Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2673838..2674363 Replicon chromosome
Accession NC_002939
Organism Geobacter sulfurreducens PCA

Toxin (Protein)


Gene name relE Uniprot ID Q74AD7
Locus tag GS_RS12260 Protein ID WP_010943076.1
Coordinates 2674073..2674363 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q74AD8
Locus tag GS_RS12255 Protein ID WP_010943075.1
Coordinates 2673838..2674083 (+) Length 82 a.a.

Genomic Context

GS_RS12255GS_RS12260GS_RS12235GS_RS12240GS_RS12245GS_RS12250GS_RS12265GS_RS12270GS_RS12275GS_RS12285
Location: 2673838..2674083 (246 bp)
Type: Antitoxin
Protein ID: WP_010943075.1
Location: 2674073..2674363 (291 bp)
Type: Toxin
Protein ID: WP_010943076.1
Location: 2669939..2670646 (708 bp)
Type: Others
Protein ID: WP_010943071.1
Location: 2670676..2671932 (1257 bp)
Type: Others
Protein ID: WP_010943072.1
Location: 2671948..2672934 (987 bp)
Type: Others
Protein ID: WP_010943073.1
Location: 2672975..2673460 (486 bp)
Type: Others
Protein ID: WP_010943074.1
Location: 2674412..2674828 (417 bp)
Type: Others
Protein ID: WP_010943077.1
Location: 2674956..2675702 (747 bp)
Type: Others
Protein ID: WP_010943078.1
Location: 2675927..2676949 (1023 bp)
Type: Others
Protein ID: WP_010943079.1
Location: 2677706..2678683 (978 bp)
Type: Others
Protein ID: WP_010943082.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GS_RS122352669939..2670646-708WP_010943071.1lipoyl(octanoyl) transferase LipB-
GS_RS122402670676..2671932-1257WP_010943072.12-oxo acid dehydrogenase subunit E2-
GS_RS122452671948..2672934-987WP_010943073.1alpha-ketoacid dehydrogenase subunit beta-
GS_RS122502672975..2673460-486WP_010943074.1VOC family protein-
GS_RS122552673838..2674083+246WP_010943075.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
GS_RS122602674073..2674363+291WP_010943076.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GS_RS122652674412..2674828-417WP_010943077.1hypothetical protein-
GS_RS122702674956..2675702-747WP_010943078.1class I SAM-dependent methyltransferase-
GS_RS122752675927..2676949-1023WP_010943079.1RelA/SpoT domain-containing protein-
GS_RS122852677706..2678683-978WP_010943082.1pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-67)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11331.30 Da        Isoelectric Point: 10.4995

>T20495 WP_010943076.1 NC_002939:2674073-2674363 [Geobacter sulfurreducens PCA]
MSYSLEFKESALKEWKKLDGRIREQFKKKLTERLELPRVEPARLSGMPDCYKIKLKNAGYRLVYQVDDNRIIVTVVAVGK
RENLTVYRAAEKRVKQ

Download         Length: 291 bp

>T20495 NC_002939:2674073-2674363 [Geobacter sulfurreducens PCA]
ATGAGCTATAGCCTCGAATTCAAGGAATCCGCCCTGAAGGAGTGGAAAAAACTCGATGGCAGAATCCGTGAACAGTTTAA
GAAGAAGCTTACCGAACGGCTTGAGCTTCCTCGCGTCGAGCCGGCCCGACTCTCCGGCATGCCCGATTGCTACAAAATCA
AGCTGAAGAACGCCGGCTACCGGCTGGTTTACCAGGTTGACGACAACCGCATCATCGTTACTGTCGTGGCTGTCGGAAAA
CGCGAAAACCTTACCGTTTATCGAGCGGCAGAGAAAAGGGTGAAACAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9193.46 Da        Isoelectric Point: 4.6631

>AT20495 WP_010943075.1 NC_002939:2673838-2674083 [Geobacter sulfurreducens PCA]
MERLFARASVSISDLKKNPTRIINQSEGEPVAILNHNKPSAYLIPADAFEALMEKLEDYELSQIVKEREHEPSVKVSLDE
L

Download         Length: 246 bp

>AT20495 NC_002939:2673838-2674083 [Geobacter sulfurreducens PCA]
ATGGAACGTCTTTTTGCCCGTGCCTCGGTCAGCATAAGTGACCTTAAAAAAAACCCCACCCGAATCATTAATCAGTCCGA
AGGTGAACCTGTGGCAATCCTCAACCACAACAAGCCAAGTGCATACTTAATCCCCGCCGATGCCTTCGAGGCGCTCATGG
AGAAACTGGAGGATTATGAGCTTTCCCAAATTGTGAAGGAACGGGAACACGAGCCGAGTGTCAAGGTCTCCCTCGATGAG
CTATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ74AD7

Antitoxin

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Source
ID
Structure
AlphaFold DBQ74AD8

References