Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3679241..3679946 Replicon chromosome
Accession NZ_CP076243
Organism Escherichia coli O157:H7 strain Balcarce_14.2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JKN69_RS19005 Protein ID WP_226204017.1
Coordinates 3679241..3679627 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JKN69_RS19010 Protein ID WP_226204019.1
Coordinates 3679617..3679946 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKN69_RS18985 (3675245) 3675245..3675871 + 627 WP_001295292.1 glutathione S-transferase GstB -
JKN69_RS18990 (3675868) 3675868..3676983 - 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
JKN69_RS18995 (3677094) 3677094..3677477 - 384 WP_000497137.1 biofilm formation regulator BssR -
JKN69_RS19000 (3677690) 3677690..3679015 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
JKN69_RS19005 (3679241) 3679241..3679627 + 387 WP_226204017.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JKN69_RS19010 (3679617) 3679617..3679946 + 330 WP_226204019.1 DNA-binding transcriptional regulator Antitoxin
JKN69_RS19015 (3680016) 3680016..3681344 - 1329 WP_000086905.1 GGDEF domain-containing protein -
JKN69_RS19020 (3681352) 3681352..3683700 - 2349 WP_000950320.1 EAL domain-containing protein -
JKN69_RS19025 (3683878) 3683878..3684789 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14251.37 Da        Isoelectric Point: 9.7113

>T204948 WP_226204017.1 NZ_CP076243:3679241-3679627 [Escherichia coli O157:H7]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNEQ

Download         Length: 387 bp

>T204948 NZ_CP101302:c4743743-4743363 [Escherichia coli]
ATGAAAACATTACCCGACACTCACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCTCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATCCTCCGGGCCCGCAGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTAGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11981.09 Da        Isoelectric Point: 10.2428

>AT204948 WP_226204019.1 NZ_CP076243:3679617-3679946 [Escherichia coli O157:H7]
MSNKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT204948 NZ_CP101302:c4744200-4743832 [Escherichia coli]
GTGTCAGACACACTCCATGAGACAAATTATCCCAACGACAATCACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGACGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTAGACCAGGCCTTTCCGCTACTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGGCACTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGATATGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References