Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3513111..3513589 Replicon chromosome
Accession NZ_CP076243
Organism Escherichia coli O157:H7 strain Balcarce_14.2

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag JKN69_RS18260 Protein ID WP_001303876.1
Coordinates 3513302..3513589 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag JKN69_RS18255 Protein ID WP_000536233.1
Coordinates 3513111..3513302 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKN69_RS18220 (3508515) 3508515..3509285 - 771 WP_000450992.1 DUF1627 domain-containing protein -
JKN69_RS18225 (3509307) 3509307..3510053 - 747 WP_000788745.1 ATP-binding protein -
JKN69_RS18230 (3510060) 3510060..3511151 - 1092 WP_001205823.1 hypothetical protein -
JKN69_RS18235 (3511230) 3511230..3511685 + 456 WP_000273724.1 hypothetical protein -
JKN69_RS18240 (3511892) 3511892..3512317 - 426 WP_000693855.1 toxin YdaT family protein -
JKN69_RS18245 (3512301) 3512301..3512573 - 273 WP_000887453.1 YdaS family helix-turn-helix protein -
JKN69_RS18250 (3512682) 3512682..3513083 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
JKN69_RS18255 (3513111) 3513111..3513302 + 192 WP_000536233.1 hypothetical protein Antitoxin
JKN69_RS18260 (3513302) 3513302..3513589 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JKN69_RS18265 (3513867) 3513867..3514022 + 156 WP_000379575.1 DUF1391 family protein -
JKN69_RS28035 (3514024) 3514024..3514152 + 129 WP_000344963.1 protein YdfB -
JKN69_RS18270 (3514164) 3514164..3514553 + 390 WP_000394511.1 hypothetical protein -
JKN69_RS18275 (3514740) 3514740..3514925 - 186 WP_001133046.1 hypothetical protein -
JKN69_RS18280 (3515499) 3515499..3515687 + 189 WP_000413705.1 cell division inhibition protein DicB -
JKN69_RS18285 (3515684) 3515684..3515875 + 192 WP_001098307.1 DUF1482 family protein -
JKN69_RS18290 (3515969) 3515969..3518440 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T204947 WP_001303876.1 NZ_CP076243:3513302-3513589 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T204947 NZ_CP101302:4593211-4593588 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CCACTACAGAACGGTAAATGACATTACCCTGGGTAAACGCACGGAGGCAAAACGATGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT204947 WP_000536233.1 NZ_CP076243:3513111-3513302 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT204947 NZ_CP101302:4592790-4593164 [Escherichia coli]
GTGTCAGGCACACTCCATGAGACAAATTATCCCAACGACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAATTACATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References