Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2614546..2615017 | Replicon | chromosome |
| Accession | NZ_CP076243 | ||
| Organism | Escherichia coli O157:H7 strain Balcarce_14.2 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | JKN69_RS13370 | Protein ID | WP_001303511.1 |
| Coordinates | 2614546..2614824 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | JKN69_RS13375 | Protein ID | WP_001302048.1 |
| Coordinates | 2614826..2615017 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JKN69_RS13340 (2609771) | 2609771..2610022 | - | 252 | WP_000005552.1 | excisionase family protein | - |
| JKN69_RS13345 (2610095) | 2610095..2612566 | - | 2472 | WP_000048458.1 | exonuclease | - |
| JKN69_RS13350 (2612659) | 2612659..2612850 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| JKN69_RS13355 (2612847) | 2612847..2613035 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| JKN69_RS13360 (2613604) | 2613604..2613822 | - | 219 | WP_001171930.1 | protein YdfC | - |
| JKN69_RS13365 (2613894) | 2613894..2614193 | - | 300 | WP_001240334.1 | hypothetical protein | - |
| JKN69_RS13370 (2614546) | 2614546..2614824 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JKN69_RS13375 (2614826) | 2614826..2615017 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| JKN69_RS13380 (2615038) | 2615038..2615409 | - | 372 | WP_001169686.1 | hypothetical protein | - |
| JKN69_RS13385 (2615507) | 2615507..2615809 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| JKN69_RS13390 (2615806) | 2615806..2616231 | + | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| JKN69_RS13395 (2616254) | 2616254..2617216 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| JKN69_RS13400 (2617223) | 2617223..2617963 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
| JKN69_RS13405 (2617989) | 2617989..2618758 | + | 770 | Protein_2618 | DUF1627 domain-containing protein | - |
| JKN69_RS13410 (2618774) | 2618774..2619169 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
| JKN69_RS13415 (2619226) | 2619226..2619810 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2607385..2663887 | 56502 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T204944 WP_001303511.1 NZ_CP076243:c2614824-2614546 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T204944 NZ_CP101302:c3957561-3957163 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT204944 WP_001302048.1 NZ_CP076243:c2615017-2614826 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT204944 NZ_CP101302:c3957788-3957561 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|