Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3541915..3542393 Replicon chromosome
Accession NZ_CP076241
Organism Escherichia coli O157:H7 strain Vac_07.1

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag JKN65_RS18355 Protein ID WP_001303876.1
Coordinates 3542106..3542393 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag JKN65_RS18350 Protein ID WP_000536233.1
Coordinates 3541915..3542106 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKN65_RS18315 (3537319) 3537319..3538089 - 771 WP_000450992.1 DUF1627 domain-containing protein -
JKN65_RS18320 (3538111) 3538111..3538857 - 747 WP_000788745.1 ATP-binding protein -
JKN65_RS18325 (3538864) 3538864..3539955 - 1092 WP_001205823.1 hypothetical protein -
JKN65_RS18330 (3540034) 3540034..3540489 + 456 WP_000273724.1 hypothetical protein -
JKN65_RS18335 (3540696) 3540696..3541121 - 426 WP_000693855.1 toxin YdaT family protein -
JKN65_RS18340 (3541105) 3541105..3541377 - 273 WP_000887453.1 YdaS family helix-turn-helix protein -
JKN65_RS18345 (3541486) 3541486..3541887 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
JKN65_RS18350 (3541915) 3541915..3542106 + 192 WP_000536233.1 hypothetical protein Antitoxin
JKN65_RS18355 (3542106) 3542106..3542393 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JKN65_RS18360 (3542671) 3542671..3542826 + 156 WP_000379575.1 DUF1391 family protein -
JKN65_RS27630 (3542828) 3542828..3542956 + 129 WP_000344963.1 protein YdfB -
JKN65_RS18365 (3542968) 3542968..3543357 + 390 WP_000394511.1 hypothetical protein -
JKN65_RS18370 (3543544) 3543544..3543729 - 186 WP_001133046.1 hypothetical protein -
JKN65_RS18375 (3544303) 3544303..3544491 + 189 WP_000413705.1 cell division inhibition protein DicB -
JKN65_RS18380 (3544488) 3544488..3544679 + 192 WP_001098307.1 DUF1482 family protein -
JKN65_RS18385 (3544773) 3544773..3547244 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T204918 WP_001303876.1 NZ_CP076241:3542106-3542393 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T204918 NZ_CP101292:3647193-3647570 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT204918 WP_000536233.1 NZ_CP076241:3541915-3542106 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT204918 NZ_CP101292:3646735-3647103 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
ACCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References