Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3314105..3314900 | Replicon | chromosome |
| Accession | NZ_CP076241 | ||
| Organism | Escherichia coli O157:H7 strain Vac_07.1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | B7UP43 |
| Locus tag | JKN65_RS17150 | Protein ID | WP_000854914.1 |
| Coordinates | 3314105..3314479 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0B0VS41 |
| Locus tag | JKN65_RS17155 | Protein ID | WP_001280954.1 |
| Coordinates | 3314526..3314900 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JKN65_RS17110 (3309109) | 3309109..3309600 | - | 492 | WP_001301587.1 | DUF1097 domain-containing protein | - |
| JKN65_RS17115 (3309702) | 3309702..3310256 | - | 555 | WP_001001917.1 | molecular chaperone YcdY | - |
| JKN65_RS17120 (3310280) | 3310280..3311017 | - | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| JKN65_RS17125 (3311072) | 3311072..3312010 | - | 939 | WP_000351284.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| JKN65_RS17135 (3312481) | 3312481..3313323 | - | 843 | WP_001280481.1 | DUF4942 domain-containing protein | - |
| JKN65_RS17140 (3313408) | 3313408..3313605 | - | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| JKN65_RS17145 (3313617) | 3313617..3314108 | - | 492 | WP_000976853.1 | DUF5983 family protein | - |
| JKN65_RS17150 (3314105) | 3314105..3314479 | - | 375 | WP_000854914.1 | TA system toxin CbtA family protein | Toxin |
| JKN65_RS17155 (3314526) | 3314526..3314900 | - | 375 | WP_001280954.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| JKN65_RS17160 (3315063) | 3315063..3315284 | - | 222 | WP_001220314.1 | DUF987 domain-containing protein | - |
| JKN65_RS17165 (3315347) | 3315347..3315823 | - | 477 | WP_001186738.1 | RadC family protein | - |
| JKN65_RS17170 (3315839) | 3315839..3316324 | - | 486 | WP_000214398.1 | antirestriction protein | - |
| JKN65_RS17175 (3316415) | 3316415..3317233 | - | 819 | WP_001234682.1 | DUF932 domain-containing protein | - |
| JKN65_RS17180 (3317573) | 3317573..3318643 | - | 1071 | WP_000102669.1 | patatin-like phospholipase family protein | - |
| JKN65_RS17185 (3318640) | 3318640..3319545 | - | 906 | WP_000203541.1 | diguanylate cyclase regulator RdcB family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14117.17 Da Isoelectric Point: 7.7761
>T204917 WP_000854914.1 NZ_CP076241:c3314479-3314105 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T204917 NZ_CP101292:c3436528-3436425 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT
Antitoxin
Download Length: 125 a.a. Molecular weight: 13718.51 Da Isoelectric Point: 6.6249
>AT204917 WP_001280954.1 NZ_CP076241:c3314900-3314526 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT204917 NZ_CP101292:3436424-3436658 [Escherichia coli]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LXR5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0B0VS41 |