Detailed information of TA system TA020491

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3381447..3382083
• Replicon: chromosome
• Accession: NC_002928
• Organism: Bordetella parapertussis 12822

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q7W5Z1
• Locus tag: BPP_RS15835
• Protein ID: WP_010928914.1
• Coordinates: 3381447..3381629 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q7W5Z0
• Locus tag: BPP_RS15840
• Protein ID: WP_010928915.1
• Coordinates: 3381691..3382083 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BPP_RS15820	3377021..3377698	+	678	WP_010928910.1	HAD-IA family hydrolase	-
BPP_RS15825	3377916..3379103	+	1188	WP_010928911.1	MFS transporter	-
BPP_RS15830	3379678..3380898	+	1221	WP_010928912.1	ISL3-like element IS1001 family transposase	-
BPP_RS15835	3381447..3381629	+	183	WP_010928914.1	type II toxin-antitoxin system HicA family toxin	Toxin
BPP_RS15840	3381691..3382083	+	393	WP_010928915.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BPP_RS15845	3382356..3383265	-	910	Protein_3138	LysR family transcriptional regulator	-
BPP_RS15850	3383390..3384364	+	975	WP_010928916.1	tripartite tricarboxylate transporter substrate binding protein	-
BPP_RS15855	3384399..3384758	+	360	WP_010928917.1	hypothetical protein	-
BPP_RS15860	3384825..3385997	+	1173	WP_010928918.1	thiolase domain-containing protein	-
BPP_RS15865	3386001..3386427	+	427	Protein_3142	OB-fold domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3379678..3380898	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6572.69 Da
• Isoelectric Point: 10.9062

>T20491 WP_010928914.1 NC_002928:3381447-3381629 [Bordetella parapertussis 12822]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Nucleotide

• Length: 183 bp

>T20491 NC_002928:3381447-3381629 [Bordetella parapertussis 12822]
ATGGACGGCAAAGAACTGATCAAGCAGCTTGAGCGGTCCGGGTGGACACTGCGGAGCGTTAAGGGCTCCCACCACGTTTT
CGCCCACCCAGACCGCCCCGGACATATCAGCGTCCCTCACCCTAAAAAGGATCTCGGCATCGGACTACTAAACAGCATCC
TCAAAGCAGCTGGTTTGAAGTGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14058.82 Da
• Isoelectric Point: 4.2876

>AT20491 WP_010928915.1 NC_002928:3381691-3382083 [Bordetella parapertussis 12822]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT20491 NC_002928:3381691-3382083 [Bordetella parapertussis 12822]
GTGAAATATCCCATTGCCATTGAACCCGGCAGCGACACGCGCGCCTGGGGAGTCGTTGTTCCTGATCTGCCCGGCTGCTT
TTCCGCAGCGGACGAAGGGATTGATCAAGCAATCGAGAACGCCAAGGAAGCCATTGAGTTGTGGATTGAAACGGCCATCG
ACTCCGGCGCCCCCATTCCTGCGGCAACCAACATAGCCAATCATCAGGCCAATCCTGAGTTCGCCAACTGGATTTGGGCG
ATTGCTGATGTCGATCCTGCAGTCTTGGATGAAACTGTCGAGCGCGTGAACATCACAATCCCGCGCCGAATTCTCAAGCG
CCTGGATGATCGCGCCCGCGCCGCCGGCGAAAGCCGGAGCAGCTACATCGCACATCTCGCCATGACTGCCTGA

Structures

Toxin

• AlphaFold DB: Q7W5Z1

Antitoxin

• AlphaFold DB: Q7W5Z0