Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 375341..375972 | Replicon | chromosome |
Accession | NZ_CP076241 | ||
Organism | Escherichia coli O157:H7 strain Vac_07.1 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | U9Y2A7 |
Locus tag | JKN65_RS01780 | Protein ID | WP_001259385.1 |
Coordinates | 375341..375616 (+) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | U9Y7E1 |
Locus tag | JKN65_RS01785 | Protein ID | WP_000593555.1 |
Coordinates | 375613..375972 (+) | Length | 120 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JKN65_RS01765 (370345) | 370345..371412 | + | 1068 | WP_000361458.1 | HlyD family secretion protein | - |
JKN65_RS01770 (371409) | 371409..374144 | + | 2736 | WP_000149107.1 | ribosome-associated ATPase/putative transporter RbbA | - |
JKN65_RS01775 (374144) | 374144..375268 | + | 1125 | WP_001301659.1 | ABC transporter permease | - |
JKN65_RS01780 (375341) | 375341..375616 | + | 276 | WP_001259385.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
JKN65_RS01785 (375613) | 375613..375972 | + | 360 | WP_000593555.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
JKN65_RS01790 (376022) | 376022..376882 | - | 861 | WP_001131788.1 | class II aldolase | - |
JKN65_RS01795 (376914) | 376914..377183 | - | 270 | WP_000933060.1 | HPr family phosphocarrier protein | - |
JKN65_RS01800 (377173) | 377173..378681 | - | 1509 | WP_001301773.1 | FGGY-family carbohydrate kinase | - |
JKN65_RS01805 (378674) | 378674..380032 | - | 1359 | WP_001302220.1 | PTS galactitol transporter subunit IIC | - |
JKN65_RS01810 (380109) | 380109..380390 | - | 282 | WP_000084025.1 | PTS sugar transporter subunit IIB | - |
JKN65_RS01815 (380387) | 380387..380860 | - | 474 | WP_001161553.1 | PTS sugar transporter subunit IIA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 366485..375972 | 9487 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10199.94 Da Isoelectric Point: 10.7076
>T204900 WP_001259385.1 NZ_CP076241:375341-375616 [Escherichia coli O157:H7]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP
Download Length: 276 bp
>T204900 NZ_CP101291:c2165631-2165305 [Alteromonas sp. LMIT006]
ATGAAAAGTGTATTTGTTGAATCAAGCATATTTGAAAAGTACCGAAATGAATATCTCAATGACGAAGAGTTTCGACTGTT
CCAAGCTGAACTAATGTCGAACCCGAAGCAAGGTGATGTAATTCAAGGTACAGGTGGTTTGCGAAAGATCCGAGTAGCAA
GTAAAGGTAAAGGAAAGCGTGGTGGTTCACGTGTTATCTATTATTTCCTCGATGAAAAGCGTCGTTTTTATTTGCTAACC
ATTTACGGCAAAAATGAAATGGCAGACTTAACCGCATATCAAAAGAAACAGTTAAAAGCTTTTATGGAGGCGTGGCGCAA
TGAGTAA
ATGAAAAGTGTATTTGTTGAATCAAGCATATTTGAAAAGTACCGAAATGAATATCTCAATGACGAAGAGTTTCGACTGTT
CCAAGCTGAACTAATGTCGAACCCGAAGCAAGGTGATGTAATTCAAGGTACAGGTGGTTTGCGAAAGATCCGAGTAGCAA
GTAAAGGTAAAGGAAAGCGTGGTGGTTCACGTGTTATCTATTATTTCCTCGATGAAAAGCGTCGTTTTTATTTGCTAACC
ATTTACGGCAAAAATGAAATGGCAGACTTAACCGCATATCAAAAGAAACAGTTAAAAGCTTTTATGGAGGCGTGGCGCAA
TGAGTAA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13402.27 Da Isoelectric Point: 5.1987
>AT204900 WP_000593555.1 NZ_CP076241:375613-375972 [Escherichia coli O157:H7]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL
Download Length: 360 bp
>AT204900 NZ_CP101291:c2165312-2164998 [Alteromonas sp. LMIT006]
ATGAGTAATCGTGACCTATTTGCAGAGCTAAGTTCTGCACTTGTTGAAGCTAAGGAGCATTCAGAGGGTAAAGTGACTCT
GAAAACTCACCAAGTAAATGACATTAGTGAATTAGATATTTCGCCTGATGAAATAGTTAGTATTCGTGAGCAGTTTAATA
TGTCTCGTGGTGTATTTGCTCGTTTACTGCATACATCATCACGCACATTGGAAAACTGGGAGCAAGGGCGTAGCGCACCT
AATGGGCAAGCTGTTACTCTTCTAAAGTTGGTACAGCGTCATCCAGAAACACTGTCGCACATCGCAGAGCTATAA
ATGAGTAATCGTGACCTATTTGCAGAGCTAAGTTCTGCACTTGTTGAAGCTAAGGAGCATTCAGAGGGTAAAGTGACTCT
GAAAACTCACCAAGTAAATGACATTAGTGAATTAGATATTTCGCCTGATGAAATAGTTAGTATTCGTGAGCAGTTTAATA
TGTCTCGTGGTGTATTTGCTCGTTTACTGCATACATCATCACGCACATTGGAAAACTGGGAGCAAGGGCGTAGCGCACCT
AATGGGCAAGCTGTTACTCTTCTAAAGTTGGTACAGCGTCATCCAGAAACACTGTCGCACATCGCAGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4P7TTW8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LKZ6 |