Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3727517..3728222 Replicon chromosome
Accession NZ_CP076237
Organism Escherichia coli O157:H7 strain 146N4

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag JKN67_RS19205 Protein ID WP_000539519.1
Coordinates 3727517..3727903 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JKN67_RS19210 Protein ID WP_001280945.1
Coordinates 3727893..3728222 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKN67_RS19185 (3723521) 3723521..3724147 + 627 WP_001295292.1 glutathione S-transferase GstB -
JKN67_RS19190 (3724144) 3724144..3725259 - 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
JKN67_RS19195 (3725370) 3725370..3725753 - 384 WP_000497137.1 biofilm formation regulator BssR -
JKN67_RS19200 (3725966) 3725966..3727291 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
JKN67_RS19205 (3727517) 3727517..3727903 + 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JKN67_RS19210 (3727893) 3727893..3728222 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
JKN67_RS19215 (3728292) 3728292..3729620 - 1329 WP_000086905.1 GGDEF domain-containing protein -
JKN67_RS19220 (3729628) 3729628..3731976 - 2349 WP_000950320.1 EAL domain-containing protein -
JKN67_RS19225 (3732154) 3732154..3733065 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T204890 WP_000539519.1 NZ_CP076237:3727517-3727903 [Escherichia coli O157:H7]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T204890 NZ_CP101275:c79988-79839 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT204890 WP_001280945.1 NZ_CP076237:3727893-3728222 [Escherichia coli O157:H7]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT204890 NZ_CP101275:80032-80093 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References