Detailed information of TA system TA020489

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2225388..2225982
• Replicon: chromosome
• Accession: NC_002928
• Organism: Bordetella parapertussis 12822

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: BPP_RS22540
• Protein ID: WP_010928352.1
• Coordinates: 2225800..2225982 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: BPP_RS10455
• Protein ID: WP_010928351.1
• Coordinates: 2225388..2225777 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BPP_RS10430	2221231..2222271	+	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-
BPP_RS10435	2222406..2223422	+	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
BPP_RS10440	2223444..2224301	+	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
BPP_RS10445	2224346..2225122	+	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
BPP_RS10455	2225388..2225777	-	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BPP_RS22540	2225800..2225982	-	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
BPP_RS10460	2226390..2227088	+	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
BPP_RS10465	2227092..2228861	+	1770	WP_010928353.1	GMC family oxidoreductase	-
BPP_RS10470	2228872..2230227	+	1356	WP_003809657.1	cytochrome c	-
BPP_RS10475	2230239..2230979	-	741	WP_003809659.1	carbonic anhydrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T20489 WP_010928352.1 NC_002928:c2225982-2225800 [Bordetella parapertussis 12822]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T20489 NC_002928:c2225982-2225800 [Bordetella parapertussis 12822]
ATGAACAGCACAGACCTGATCCAGCAACCGAAGGCCGACGGCTGGTATCGCGTGCATACCGTGGGTTCACACCACCAGTA
CAAGCACCCGACCAAGCCCGGCAAGGTCACCGTGCCGCATCCCAGGAAGGGCCTGCCGACAGCGACACAGCGCAGCATCC
TTAAGCAAGCCGGCCTGCGATAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT20489 WP_010928351.1 NC_002928:c2225777-2225388 [Bordetella parapertussis 12822]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT20489 NC_002928:c2225777-2225388 [Bordetella parapertussis 12822]
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGCCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCTGAAGCGTGGGCCAACGATGAGGACTATCAAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAACACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAGCACGAAATGGCCGACGCCTAG

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7