Detailed information of TA system TA020488

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-brnA/BrnT_toxin-BrnA
• Location: 2091210..2091741
• Replicon: chromosome
• Accession: NC_002928
• Organism: Bordetella parapertussis 12822

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: K0MH61
• Locus tag: BPP_RS09825
• Protein ID: WP_003812626.1
• Coordinates: 2091475..2091741 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: K0MF02
• Locus tag: BPP_RS22530
• Protein ID: WP_003816743.1
• Coordinates: 2091210..2091488 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BPP_RS09800	2086640..2087734	+	1095	WP_003812637.1	TRAP transporter substrate-binding protein	-
BPP_RS09805	2087946..2088575	+	630	WP_010928293.1	TRAP transporter small permease subunit	-
BPP_RS09810	2088578..2090245	+	1668	WP_010928294.1	TRAP transporter large permease subunit	-
BPP_RS09815	2090260..2090916	+	657	WP_010928295.1	phosphoribosylanthranilate isomerase	-
BPP_RS22530	2091210..2091488	-	279	WP_003816743.1	BrnA antitoxin family protein	Antitoxin
BPP_RS09825	2091475..2091741	-	267	WP_003812626.1	BrnT family toxin	Toxin
BPP_RS09830	2091972..2093513	-	1542	WP_010928296.1	M81 family metallopeptidase	-
BPP_RS09835	2093575..2094453	-	879	WP_041937387.1	tripartite tricarboxylate transporter substrate binding protein	-
BPP_RS09840	2094850..2095482	+	633	WP_003812619.1	PAS domain-containing protein	-
BPP_RS09845	2095593..2096303	+	711	WP_003812617.1	aquaporin Z	-
BPP_RS09850	2096342..2096614	-	273	WP_003812615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-81)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (12-86)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10037.47 Da
• Isoelectric Point: 7.9923

>T20488 WP_003812626.1 NC_002928:c2091741-2091475 [Bordetella parapertussis 12822]
MDITYDPAKNDKNIADRGLSFELVCGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Nucleotide

• Length: 267 bp

>T20488 NC_002928:c2091741-2091475 [Bordetella parapertussis 12822]
ATGGATATCACCTACGACCCCGCCAAGAACGACAAGAACATTGCCGATCGCGGCCTGTCGTTCGAGTTGGTGTGTGGCTT
CGAGTGGGCCAGCGCGCTGGTGGTTGAGGATACCCGCCAGGTCTACGCCGAAACGCGCTATCAGGCGCTGGGCAAAATCG
ATGGCCGGCTCCATATGGTGGTATTCACGGTGCGCGGCGAGTCGCTGCGCATCATCAGCCTGCGTAAGGCAAATGCTCGT
GAGGTAGCTCGTTATGAAAAAGCCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10412.89 Da
• Isoelectric Point: 10.5548

>AT20488 WP_003816743.1 NC_002928:c2091488-2091210 [Bordetella parapertussis 12822]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Nucleotide

• Length: 279 bp

>AT20488 NC_002928:c2091488-2091210 [Bordetella parapertussis 12822]
ATGAAAAAGCCTGACCCCGAAAAGATTGACCGCGACAACCCCGAATGGACGGACGCGGAATTTCGGCGGGCCAAGCCGGC
CGCCGAAGTACTGCCCGAGTCGGTGCACGCGATGCTCGGCATTCGTCGCCGTGGGCCTCAAAAGACACCCACCAAACAGG
TCGTCACCATCCGGCTATCGCCTGACGTGGTAGAAGCCTTCAAGGCCTCCGGCACCGGTTGGCAGACTCGCGTGGATGCA
GCCCTGCGGGATTGGCTGAAGACGCACCAGCCTGGCTAG

Structures

Toxin

• AlphaFold DB: K0MH61

Antitoxin

• AlphaFold DB: K0MF02