Detailed information of TA system TA020487

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1504557..1505218
• Replicon: chromosome
• Accession: NC_002928
• Organism: Bordetella parapertussis 12822

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: BPP_RS07000
• Protein ID: WP_003812073.1
• Coordinates: 1504557..1504982 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BPP_RS07005
• Protein ID: WP_003812071.1
• Coordinates: 1504979..1505218 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BPP_RS06980	1500371..1501348	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
BPP_RS06985	1501369..1501881	-	513	WP_010928017.1	hypothetical protein	-
BPP_RS06990	1502380..1503885	+	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
BPP_RS06995	1503983..1504447	-	465	WP_003812075.1	MarR family transcriptional regulator	-
BPP_RS07000	1504557..1504982	-	426	WP_003812073.1	PIN domain-containing protein	Toxin
BPP_RS07005	1504979..1505218	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
BPP_RS07010	1505292..1506134	-	843	WP_010928019.1	AraC family transcriptional regulator	-
BPP_RS07015	1506272..1506817	+	546	WP_010928020.1	peroxidase-related enzyme	-
BPP_RS07020	1506876..1507388	+	513	WP_003812062.1	redoxin domain-containing protein	-
BPP_RS07025	1507469..1507702	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
BPP_RS07030	1507699..1508259	+	561	WP_010928021.1	DUF488 domain-containing protein	-
BPP_RS07035	1508337..1509383	+	1047	WP_010928022.1	Dyp-type peroxidase	-
BPP_RS07040	1509380..1510183	+	804	WP_003812055.1	bacteriocin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T20487 WP_003812073.1 NC_002928:c1504982-1504557 [Bordetella parapertussis 12822]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T20487 NC_002928:c1504982-1504557 [Bordetella parapertussis 12822]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAGCCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGGCTGGCCCGCCTGCCGCGCGGCA
AGCGGGCCGAGGCCTTGCGCCACGAATTCGAGCGGCGCGTCCTGCCGCTGTTCATGGGCCATGTCCTGCCCTTCGACACG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCAATCGATGGTTGCAT
CGCCGCCATCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCGCCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT20487 WP_003812071.1 NC_002928:c1505218-1504979 [Bordetella parapertussis 12822]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT20487 NC_002928:c1505218-1504979 [Bordetella parapertussis 12822]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCTCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: Q7WAH5