Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3657650..3658355 Replicon chromosome
Accession NZ_CP076235
Organism Escherichia coli O157:H7 strain 9.1_Anguil

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag JKN68_RS18820 Protein ID WP_000539519.1
Coordinates 3657650..3658036 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JKN68_RS18825 Protein ID WP_001280945.1
Coordinates 3658026..3658355 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKN68_RS18800 (3653654) 3653654..3654280 + 627 WP_001295292.1 glutathione S-transferase GstB -
JKN68_RS18805 (3654277) 3654277..3655392 - 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
JKN68_RS18810 (3655503) 3655503..3655886 - 384 WP_000497137.1 biofilm formation regulator BssR -
JKN68_RS18815 (3656099) 3656099..3657424 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
JKN68_RS18820 (3657650) 3657650..3658036 + 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JKN68_RS18825 (3658026) 3658026..3658355 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
JKN68_RS18830 (3658425) 3658425..3659753 - 1329 WP_000086905.1 GGDEF domain-containing protein -
JKN68_RS18835 (3659761) 3659761..3662109 - 2349 WP_000950320.1 EAL domain-containing protein -
JKN68_RS18840 (3662287) 3662287..3663198 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T204853 WP_000539519.1 NZ_CP076235:3657650-3658036 [Escherichia coli O157:H7]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T204853 NZ_CP101269:2754288-2754395 [Escherichia coli]
ATGACGCTCGCGCAGTTTACCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT204853 WP_001280945.1 NZ_CP076235:3658026-3658355 [Escherichia coli O157:H7]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT204853 NZ_CP101269:c2754241-2754175 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References