Detailed information of TA system TA020485

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2626915..2627576
• Replicon: chromosome
• Accession: NC_002927
• Organism: Bordetella bronchiseptica RB50

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0H3LNE0
• Locus tag: AYT36_RS12595
• Protein ID: WP_010926525.1
• Coordinates: 2626915..2627340 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: AYT36_RS12600
• Protein ID: WP_003812071.1
• Coordinates: 2627337..2627576 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYT36_RS12575	2622729..2623706	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
AYT36_RS12580	2623727..2624239	-	513	WP_003812080.1	hypothetical protein	-
AYT36_RS12585	2624738..2626243	+	1506	WP_003812078.1	tripartite tricarboxylate transporter permease	-
AYT36_RS12590	2626341..2626805	-	465	WP_003812075.1	MarR family transcriptional regulator	-
AYT36_RS12595	2626915..2627340	-	426	WP_010926525.1	PIN domain-containing protein	Toxin
AYT36_RS12600	2627337..2627576	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
AYT36_RS12605	2627650..2628492	-	843	WP_003812068.1	AraC family transcriptional regulator	-
AYT36_RS12610	2628630..2629175	+	546	WP_003812065.1	peroxidase-related enzyme	-
AYT36_RS12615	2629234..2629746	+	513	WP_010926526.1	redoxin domain-containing protein	-
AYT36_RS12620	2629827..2630060	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
AYT36_RS12625	2630057..2630617	+	561	WP_010926528.1	DUF488 domain-containing protein	-
AYT36_RS12630	2630695..2631741	+	1047	WP_010926529.1	Dyp-type peroxidase	-
AYT36_RS12635	2631738..2632541	+	804	WP_003812055.1	bacteriocin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T20485 WP_010926525.1 NC_002927:c2627340-2626915 [Bordetella bronchiseptica RB50]
MILLDTDVLLEPLRPAPDPAVAAWLDGQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRILPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T20485 NC_002927:c2627340-2626915 [Bordetella bronchiseptica RB50]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAGCCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGG
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGGCTGGCCCGCCTGCCGCGCGGCA
AGCGGGCCGAGGCCCTGCGCCACGAATTCGAGCGGCGCATCCTGCCGCTGTTCATGGGCCATGTCCTGCCCTTCGACACG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCAATCGATGGCTGCAT
CGCCGCCATCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCGCCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT20485 WP_003812071.1 NC_002927:c2627576-2627337 [Bordetella bronchiseptica RB50]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT20485 NC_002927:c2627576-2627337 [Bordetella bronchiseptica RB50]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGGGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCCCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: A0A0H3LNE0