Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3842553..3843024 Replicon chromosome
Accession NZ_CP076232
Organism Escherichia coli O157:H7 strain 7.1_Anguil

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag XE90_RS19425 Protein ID WP_001303511.1
Coordinates 3842553..3842831 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag XE90_RS19430 Protein ID WP_001302048.1
Coordinates 3842833..3843024 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XE90_RS19395 (3837778) 3837778..3838029 - 252 WP_000005552.1 excisionase family protein -
XE90_RS19400 (3838102) 3838102..3840573 - 2472 WP_000048458.1 exonuclease -
XE90_RS19405 (3840666) 3840666..3840857 - 192 WP_001090200.1 DUF1482 family protein -
XE90_RS19410 (3840854) 3840854..3841042 - 189 WP_000449192.1 cell division inhibition protein DicB -
XE90_RS19415 (3841611) 3841611..3841829 - 219 WP_001171930.1 protein YdfC -
XE90_RS19420 (3841901) 3841901..3842200 - 300 WP_001240334.1 hypothetical protein -
XE90_RS19425 (3842553) 3842553..3842831 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XE90_RS19430 (3842833) 3842833..3843024 - 192 WP_001302048.1 hypothetical protein Antitoxin
XE90_RS19435 (3843045) 3843045..3843416 - 372 WP_001169686.1 hypothetical protein -
XE90_RS19440 (3843514) 3843514..3843816 + 303 WP_000172738.1 transcriptional regulator -
XE90_RS19445 (3843813) 3843813..3844238 + 426 WP_000693943.1 toxin YdaT family protein -
XE90_RS19450 (3844261) 3844261..3845222 + 962 Protein_3795 helix-turn-helix domain-containing protein -
XE90_RS19455 (3845229) 3845229..3845969 + 741 WP_000788938.1 ATP-binding protein -
XE90_RS19460 (3845995) 3845995..3846764 + 770 Protein_3797 DUF1627 domain-containing protein -
XE90_RS19465 (3846780) 3846780..3847175 + 396 WP_001118159.1 DUF977 family protein -
XE90_RS19470 (3847205) 3847205..3847309 + 105 Protein_3799 hypothetical protein -
XE90_RS19475 (3847296) 3847296..3847370 + 75 Protein_3800 DUF977 family protein -
XE90_RS19480 (3847427) 3847427..3848011 + 585 WP_000206793.1 DUF551 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3822545..3881846 59301


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T204819 WP_001303511.1 NZ_CP076232:c3842831-3842553 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T204819 NZ_CP101259:39081-39233 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT204819 WP_001302048.1 NZ_CP076232:c3843024-3842833 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT204819 NZ_CP101259:c39029-38969 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References