Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 1118660..1119255 Replicon chromosome
Accession NZ_CP076232
Organism Escherichia coli O157:H7 strain 7.1_Anguil

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag XE90_RS05435 Protein ID WP_000239579.1
Coordinates 1118905..1119255 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID Q8XCF3
Locus tag XE90_RS05430 Protein ID WP_001223210.1
Coordinates 1118660..1118911 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XE90_RS05420 (1114325) 1114325..1118104 + 3780 WP_046424167.1 autotransporter assembly complex protein TamB -
XE90_RS05425 (1118107) 1118107..1118448 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
XE90_RS05430 (1118660) 1118660..1118911 + 252 WP_001223210.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
XE90_RS05435 (1118905) 1118905..1119255 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
XE90_RS05440 (1119335) 1119335..1119865 - 531 WP_000055075.1 inorganic diphosphatase -
XE90_RS05445 (1120175) 1120175..1121131 + 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
XE90_RS05450 (1121271) 1121271..1122773 + 1503 WP_000205806.1 sugar ABC transporter ATP-binding protein -
XE90_RS05455 (1122787) 1122787..1123809 + 1023 WP_001301928.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T204800 WP_000239579.1 NZ_CP076232:1118905-1119255 [Escherichia coli O157:H7]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T204800 NZ_CP101253:39081-39233 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9299.64 Da        Isoelectric Point: 4.4201

>AT204800 WP_001223210.1 NZ_CP076232:1118660-1118911 [Escherichia coli O157:H7]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT204800 NZ_CP101253:c39029-38969 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure

References