Detailed information of TA system TA204764

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 992660..994022
• Replicon: chromosome
• Accession: NZ_CP076229
• Organism: Mycoplasmopsis bovis strain Mb191

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: KM150_RS04285
• Protein ID: WP_238562480.1
• Coordinates: 992660..993415 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: Q934C3
• Locus tag: KM150_RS04290
• Protein ID: WP_013456322.1
• Coordinates: 993408..994022 (-)
• Length: 205 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KM150_RS04260	988132..988341	-	210	WP_041309187.1	hypothetical protein	-
KM150_RS04265	988392..988604	+	213	WP_143823062.1	hypothetical protein	-
KM150_RS04270	988997..989950	-	954	WP_276515655.1	IS30 family transposase	-
KM150_RS04275	990301..991329	+	1029	WP_078086175.1	IS30-like element ISMbov1 family transposase	-
KM150_RS04280	991711..992436	-	726	WP_013456472.1	variable surface lipoprotein	-
KM150_RS04285	992660..993415	-	756	WP_238562480.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KM150_RS04290	993408..994022	-	615	WP_013456322.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
KM150_RS04295	994208..994858	+	651	WP_214461189.1	variable surface lipoprotein	-
KM150_RS04300	995022..995852	+	831	WP_238562481.1	variable surface lipoprotein	-
KM150_RS04305	995789..996364	-	576	WP_075271397.1	variable surface lipoprotein	-
KM150_RS04310	996650..997399	+	750	WP_013456123.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	990211..991329	1118

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-230)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (13-59)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 29210.70 Da
• Isoelectric Point: 8.5798

>T204764 WP_238562480.1 NZ_CP076229:c993415-992660 [Mycoplasmopsis bovis]
MNKNKLISLCHKTADENNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKST

Nucleotide

• Length: 756 bp

>T204764 NZ_CP101245:295136-295366 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 205 a.a.
• Molecular weight: 24143.83 Da
• Isoelectric Point: 9.7617

>AT204764 WP_013456322.1 NZ_CP076229:c994022-993408 [Mycoplasmopsis bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE

Nucleotide

• Length: 615 bp

>AT204764 NZ_CP101245:295363-295722 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Antitoxin

• AlphaFold DB: Q934C3