Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2316361..2317336 Replicon chromosome
Accession NZ_CP076222
Organism Bacillus anthracis strain A159

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM394_RS12115 Protein ID WP_002036394.1
Coordinates 2316361..2317098 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM394_RS12120 Protein ID WP_000588712.1
Coordinates 2317211..2317336 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM394_RS12095 (KM394_12100) 2312089..2312871 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM394_RS12100 (KM394_12105) 2312993..2314678 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
KM394_RS12105 (KM394_12110) 2314785..2315267 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM394_RS12110 (KM394_12115) 2315435..2316172 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM394_RS12115 (KM394_12120) 2316361..2317098 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM394_RS12120 (KM394_12125) 2317211..2317336 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM394_RS12125 (KM394_12130) 2317359..2317589 + 231 WP_011053163.1 stage II sporulation protein SB -
KM394_RS12130 (KM394_12135) 2317626..2317811 - 186 WP_002036392.1 hypothetical protein -
KM394_RS12135 (KM394_12140) 2318183..2318419 - 237 WP_001021688.1 hypothetical protein -
KM394_RS28820 2318556..2318681 + 126 WP_000694311.1 hypothetical protein -
KM394_RS12140 (KM394_12145) 2318758..2318934 + 177 WP_000808045.1 stage II sporulation protein SB -
KM394_RS12145 (KM394_12150) 2319078..2320547 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM394_RS12150 (KM394_12155) 2321111..2321581 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204761 WP_002036394.1 NZ_CP076222:2316361-2317098 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204761 NZ_CP101241:2212-2490 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204761 WP_000588712.1 NZ_CP076222:2317211-2317336 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204761 NZ_CP101241:1943-2212 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGGGTGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References