Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2302095..2303070 Replicon chromosome
Accession NZ_CP076219
Organism Bacillus anthracis strain AF039

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM392_RS12055 Protein ID WP_002036394.1
Coordinates 2302095..2302832 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM392_RS12060 Protein ID WP_000588712.1
Coordinates 2302945..2303070 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM392_RS12035 (KM392_12040) 2297823..2298605 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM392_RS12040 (KM392_12045) 2298727..2300412 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
KM392_RS12045 (KM392_12050) 2300519..2301001 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM392_RS12050 (KM392_12055) 2301169..2301906 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM392_RS12055 (KM392_12060) 2302095..2302832 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM392_RS12060 (KM392_12065) 2302945..2303070 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM392_RS12065 (KM392_12070) 2303093..2303323 + 231 WP_011053163.1 stage II sporulation protein SB -
KM392_RS12070 (KM392_12075) 2303360..2303545 - 186 WP_002036392.1 hypothetical protein -
KM392_RS12075 (KM392_12080) 2303917..2304153 - 237 WP_001021688.1 hypothetical protein -
KM392_RS28725 2304290..2304415 + 126 WP_000694311.1 hypothetical protein -
KM392_RS12080 (KM392_12085) 2304492..2304668 + 177 WP_000808045.1 stage II sporulation protein SB -
KM392_RS12085 (KM392_12090) 2304812..2306281 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM392_RS12090 (KM392_12095) 2306845..2307315 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204759 WP_002036394.1 NZ_CP076219:2302095-2302832 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204759 NZ_CP101240:3886174-3886326 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204759 WP_000588712.1 NZ_CP076219:2302945-2303070 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204759 NZ_CP101240:c3886125-3886068 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References