Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2316897..2317872 | Replicon | chromosome |
| Accession | NZ_CP076204 | ||
| Organism | Bacillus anthracis strain 3-IZSLT | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | A0A2R2IKP2 |
| Locus tag | KM390_RS12105 | Protein ID | WP_002036394.1 |
| Coordinates | 2316897..2317634 (+) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | R8HWP4 |
| Locus tag | KM390_RS12110 | Protein ID | WP_000588712.1 |
| Coordinates | 2317747..2317872 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KM390_RS12085 (KM390_12085) | 2312625..2313407 | + | 783 | WP_000381787.1 | class I SAM-dependent methyltransferase | - |
| KM390_RS12090 (KM390_12090) | 2313529..2315214 | - | 1686 | WP_014654562.1 | alpha-keto acid decarboxylase family protein | - |
| KM390_RS12095 (KM390_12095) | 2315321..2315803 | + | 483 | WP_000191911.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| KM390_RS12100 (KM390_12100) | 2315971..2316708 | + | 738 | WP_000594139.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| KM390_RS12105 (KM390_12105) | 2316897..2317634 | + | 738 | WP_002036394.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| KM390_RS12110 (KM390_12110) | 2317747..2317872 | + | 126 | WP_000588712.1 | hypothetical protein | Antitoxin |
| KM390_RS28745 | 2317895..2318124 | + | 230 | Protein_2326 | stage II sporulation protein SB | - |
| KM390_RS12115 (KM390_12115) | 2318161..2318442 | - | 282 | WP_001041555.1 | hypothetical protein | - |
| KM390_RS12120 (KM390_12120) | 2318719..2318955 | - | 237 | WP_001021689.1 | hypothetical protein | - |
| KM390_RS28750 | 2319092..2319217 | + | 126 | WP_000694311.1 | hypothetical protein | - |
| KM390_RS12125 (KM390_12125) | 2319294..2319470 | + | 177 | WP_000808045.1 | stage II sporulation protein SB | - |
| KM390_RS12130 (KM390_12130) | 2319614..2321083 | + | 1470 | WP_000287522.1 | beta-Ala-His dipeptidase | - |
| KM390_RS12135 (KM390_12135) | 2321647..2322117 | - | 471 | WP_000670597.1 | DUF5065 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28373.03 Da Isoelectric Point: 8.2705
>T204749 WP_002036394.1 NZ_CP076204:2316897-2317634 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T204749 NZ_CP101240:742829-743125 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 42 a.a. Molecular weight: 4938.34 Da Isoelectric Point: 3.9150
>AT204749 WP_000588712.1 NZ_CP076204:2317747-2317872 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
Download Length: 126 bp
>AT204749 NZ_CP101240:743127-743522 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2R2IKP2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A366GQT1 |