Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2316897..2317872 Replicon chromosome
Accession NZ_CP076204
Organism Bacillus anthracis strain 3-IZSLT

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM390_RS12105 Protein ID WP_002036394.1
Coordinates 2316897..2317634 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM390_RS12110 Protein ID WP_000588712.1
Coordinates 2317747..2317872 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM390_RS12085 (KM390_12085) 2312625..2313407 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM390_RS12090 (KM390_12090) 2313529..2315214 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
KM390_RS12095 (KM390_12095) 2315321..2315803 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM390_RS12100 (KM390_12100) 2315971..2316708 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM390_RS12105 (KM390_12105) 2316897..2317634 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM390_RS12110 (KM390_12110) 2317747..2317872 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM390_RS28745 2317895..2318124 + 230 Protein_2326 stage II sporulation protein SB -
KM390_RS12115 (KM390_12115) 2318161..2318442 - 282 WP_001041555.1 hypothetical protein -
KM390_RS12120 (KM390_12120) 2318719..2318955 - 237 WP_001021689.1 hypothetical protein -
KM390_RS28750 2319092..2319217 + 126 WP_000694311.1 hypothetical protein -
KM390_RS12125 (KM390_12125) 2319294..2319470 + 177 WP_000808045.1 stage II sporulation protein SB -
KM390_RS12130 (KM390_12130) 2319614..2321083 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM390_RS12135 (KM390_12135) 2321647..2322117 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204749 WP_002036394.1 NZ_CP076204:2316897-2317634 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204749 NZ_CP101240:742829-743125 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204749 WP_000588712.1 NZ_CP076204:2317747-2317872 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204749 NZ_CP101240:743127-743522 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References