Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2357523..2358498 Replicon chromosome
Accession NZ_CP076201
Organism Bacillus anthracis strain A3783

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM387_RS12370 Protein ID WP_002036394.1
Coordinates 2357523..2358260 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM387_RS12375 Protein ID WP_000588712.1
Coordinates 2358373..2358498 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM387_RS12350 (KM387_12340) 2353251..2354033 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM387_RS12355 (KM387_12345) 2354155..2355840 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
KM387_RS12360 (KM387_12350) 2355947..2356429 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM387_RS12365 (KM387_12355) 2356597..2357334 + 738 WP_000594138.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM387_RS12370 (KM387_12360) 2357523..2358260 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM387_RS12375 (KM387_12365) 2358373..2358498 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM387_RS12380 (KM387_12370) 2358521..2358751 + 231 WP_275064499.1 stage II sporulation protein SB -
KM387_RS12385 (KM387_12375) 2358788..2359069 - 282 WP_001041555.1 hypothetical protein -
KM387_RS12390 (KM387_12380) 2359346..2359582 - 237 WP_001021688.1 hypothetical protein -
KM387_RS29025 2359719..2359844 + 126 WP_000694311.1 hypothetical protein -
KM387_RS12395 (KM387_12385) 2359921..2360097 + 177 WP_000808045.1 stage II sporulation protein SB -
KM387_RS12400 (KM387_12390) 2360241..2361710 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM387_RS12405 (KM387_12395) 2362274..2362744 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204747 WP_002036394.1 NZ_CP076201:2357523-2358260 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204747 NZ_CP101240:316701-317228 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204747 WP_000588712.1 NZ_CP076201:2358373-2358498 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204747 NZ_CP101240:316428-316694 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References