Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2315674..2316649 Replicon chromosome
Accession NZ_CP076198
Organism Bacillus anthracis strain Tangail-4/2

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM391_RS12090 Protein ID WP_002036394.1
Coordinates 2315674..2316411 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM391_RS12095 Protein ID WP_000588712.1
Coordinates 2316524..2316649 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM391_RS12070 (KM391_12060) 2311402..2312184 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM391_RS12075 (KM391_12065) 2312306..2313991 - 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
KM391_RS12080 (KM391_12070) 2314098..2314580 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM391_RS12085 (KM391_12075) 2314748..2315485 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM391_RS12090 (KM391_12080) 2315674..2316411 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM391_RS12095 (KM391_12085) 2316524..2316649 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM391_RS12100 (KM391_12090) 2316672..2316902 + 231 WP_011053163.1 stage II sporulation protein SB -
KM391_RS12105 (KM391_12095) 2316939..2317220 - 282 WP_001041555.1 hypothetical protein -
KM391_RS12110 (KM391_12100) 2317497..2317733 - 237 WP_001021689.1 hypothetical protein -
KM391_RS28755 2317870..2317995 + 126 WP_000694311.1 hypothetical protein -
KM391_RS12115 (KM391_12105) 2318072..2318248 + 177 WP_000808045.1 stage II sporulation protein SB -
KM391_RS12120 (KM391_12110) 2318392..2319861 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM391_RS12125 (KM391_12115) 2320425..2320895 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204745 WP_002036394.1 NZ_CP076198:2315674-2316411 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204745 NZ_CP101237:2070-2357 [Escherichia coli]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204745 WP_000588712.1 NZ_CP076198:2316524-2316649 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204745 NZ_CP101237:1822-2073 [Escherichia coli]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References