Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2316476..2317451 Replicon chromosome
Accession NZ_CP076195
Organism Bacillus anthracis strain 188678-1

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM396_RS12080 Protein ID WP_002036394.1
Coordinates 2316476..2317213 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM396_RS12085 Protein ID WP_000588712.1
Coordinates 2317326..2317451 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM396_RS12060 (KM396_12060) 2312204..2312986 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM396_RS12065 (KM396_12065) 2313108..2314793 - 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
KM396_RS12070 (KM396_12070) 2314900..2315382 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM396_RS12075 (KM396_12075) 2315550..2316287 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM396_RS12080 (KM396_12080) 2316476..2317213 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM396_RS12085 (KM396_12085) 2317326..2317451 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM396_RS12090 (KM396_12090) 2317474..2317704 + 231 WP_011053163.1 stage II sporulation protein SB -
KM396_RS12095 (KM396_12095) 2317741..2318022 - 282 WP_001041555.1 hypothetical protein -
KM396_RS12100 (KM396_12100) 2318299..2318535 - 237 WP_001021689.1 hypothetical protein -
KM396_RS28735 2318672..2318797 + 126 WP_000694311.1 hypothetical protein -
KM396_RS12105 (KM396_12105) 2318874..2319050 + 177 WP_000808045.1 stage II sporulation protein SB -
KM396_RS12110 (KM396_12110) 2319194..2320663 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM396_RS12115 (KM396_12115) 2321227..2321697 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204743 WP_002036394.1 NZ_CP076195:2316476-2317213 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204743 NZ_CP101235:40772-41149 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAGCTTACTGCAATTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCAGGCATGTC
AGATTCGGGAAGAGCTGAGGCTATTATCGGGAGAGTCCAGGCCAGAGTTGCATATGAAGAGATTACCGACCTTTTCGAAG
TCTCCGCAACTTACCTGGTGGCTACTGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
TTGTTATTTCTGCGCCGTAACGGTGTGCAGGTATATGATTCACCAGAACTGGCAGAGCTTACTGTGGGGGCTGCGACCGG
AGAGGTATCCGTATCTACTGTCGTTGCCACGTTACGTAGATTGTATGGTACGGCGTAG

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204743 WP_000588712.1 NZ_CP076195:2317326-2317451 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204743 NZ_CP101235:40551-40772 [Escherichia coli]
ATGCAATCTATTAACTTCCGTACCGCACGCAGCAATCTTACCGAAGTGCTCAACAATGTTGAAGCCGGAGAAGAGGTTGA
AATCACCCGTAGAGGCCGTGAGCCAGCTGTAATTGTCAGCAAGGCCACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTCGCATCCCTGTTTGACACTCTGGACACCACCAATAAGAAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References