Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2317057..2318032 Replicon chromosome
Accession NZ_CP076192
Organism Bacillus anthracis strain UR-1

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM399_RS12125 Protein ID WP_002036394.1
Coordinates 2317057..2317794 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM399_RS12130 Protein ID WP_000588712.1
Coordinates 2317907..2318032 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM399_RS12105 (KM399_12095) 2312785..2313567 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM399_RS12110 (KM399_12100) 2313689..2315374 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
KM399_RS12115 (KM399_12105) 2315481..2315963 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM399_RS12120 (KM399_12110) 2316131..2316868 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM399_RS12125 (KM399_12115) 2317057..2317794 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM399_RS12130 (KM399_12120) 2317907..2318032 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM399_RS12135 (KM399_12125) 2318055..2318285 + 231 WP_011053163.1 stage II sporulation protein SB -
KM399_RS12140 (KM399_12130) 2318322..2318603 - 282 WP_001041555.1 hypothetical protein -
KM399_RS12145 (KM399_12135) 2318880..2319116 - 237 WP_001021689.1 hypothetical protein -
KM399_RS28840 2319253..2319378 + 126 WP_000694311.1 hypothetical protein -
KM399_RS12150 (KM399_12140) 2319455..2319631 + 177 WP_000808045.1 stage II sporulation protein SB -
KM399_RS12155 (KM399_12145) 2319775..2321244 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM399_RS12160 (KM399_12150) 2321808..2322278 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204741 WP_002036394.1 NZ_CP076192:2317057-2317794 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204741 NZ_CP101233:c4062678-4062505 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204741 WP_000588712.1 NZ_CP076192:2317907-2318032 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204741 NZ_CP101233:c4063002-4062706 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References