20474

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2145455..2145993 Replicon chromosome
Accession NC_002758
Organism Staphylococcus aureus subsp. aureus Mu50

Toxin (Protein)


Gene name TscT Uniprot ID A0A0H3K0C1
Locus tag SAV_RS11045 Protein ID WP_001078344.1
Coordinates 2145455..2145781 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A0H3JSN0
Locus tag SAV_RS11050 Protein ID WP_001058495.1
Coordinates 2145784..2145993 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAV_RS11020 2140681..2141022 - 342 WP_001190615.1 hypothetical protein -
SAV_RS11025 2141470..2142111 - 642 WP_001047698.1 hypothetical protein -
SAV_RS11030 2142108..2142488 - 381 WP_000356942.1 hypothetical protein -
SAV_RS11035 2142798..2144507 - 1710 WP_000447473.1 DUF927 domain-containing protein -
SAV_RS11040 2144521..2145390 - 870 WP_001002689.1 primase alpha helix C-terminal domain-containing protein -
SAV_RS11045 2145455..2145781 - 327 WP_001078344.1 DUF1474 family protein Toxin
SAV_RS11050 2145784..2145993 - 210 WP_001058495.1 hypothetical protein Antitoxin
SAV_RS11055 2145986..2146132 - 147 WP_000784885.1 hypothetical protein -
SAV_RS11060 2146129..2146446 - 318 WP_000481967.1 helix-turn-helix domain-containing protein -
SAV_RS11065 2146451..2146669 - 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
SAV_RS11070 2146842..2147516 + 675 WP_000620857.1 helix-turn-helix transcriptional regulator -
SAV_RS11075 2147530..2148702 + 1173 WP_000179343.1 site-specific integrase -
SAV_RS11080 2148771..2150387 - 1617 WP_000240642.1 chaperonin GroEL -
SAV_RS11085 2150463..2150747 - 285 WP_000917289.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / sea / hlb / sell / sec / tsst-1 / groEL 2084317..2150747 66430


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12968.26 Da        Isoelectric Point: 4.3050

>T20474 WP_001078344.1 NC_002758:c2145781-2145455 [Staphylococcus aureus subsp. aureus Mu50]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T20474 NC_002758:c2145781-2145455 [Staphylococcus aureus subsp. aureus Mu50]
ATGAATCGGGAAATTAAAGATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8206.22 Da        Isoelectric Point: 4.3718

>AT20474 WP_001058495.1 NC_002758:c2145993-2145784 [Staphylococcus aureus subsp. aureus Mu50]
MNNEQKEVIEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT20474 NC_002758:c2145993-2145784 [Staphylococcus aureus subsp. aureus Mu50]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCGTGAATAATTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K0C1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3JSN0

References