Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2286388..2287363 Replicon chromosome
Accession NZ_CP076190
Organism Bacillus anthracis strain Pasteur

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM393_RS11960 Protein ID WP_002036394.1
Coordinates 2286388..2287125 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM393_RS11965 Protein ID WP_000588712.1
Coordinates 2287238..2287363 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM393_RS11940 (KM393_11955) 2282116..2282898 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM393_RS11945 (KM393_11960) 2283020..2284705 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
KM393_RS11950 (KM393_11965) 2284812..2285294 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM393_RS11955 (KM393_11970) 2285462..2286199 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM393_RS11960 (KM393_11975) 2286388..2287125 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM393_RS11965 (KM393_11980) 2287238..2287363 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM393_RS11970 (KM393_11985) 2287386..2287616 + 231 WP_011053163.1 stage II sporulation protein SB -
KM393_RS11975 (KM393_11990) 2287653..2287934 - 282 WP_001041555.1 hypothetical protein -
KM393_RS11980 (KM393_11995) 2288211..2288447 - 237 WP_001021689.1 hypothetical protein -
KM393_RS27760 2288584..2288709 + 126 WP_000694311.1 hypothetical protein -
KM393_RS11985 (KM393_12000) 2288786..2288962 + 177 WP_000808045.1 stage II sporulation protein SB -
KM393_RS11990 (KM393_12005) 2289106..2290575 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM393_RS11995 (KM393_12010) 2291139..2291609 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204739 WP_002036394.1 NZ_CP076190:2286388-2287125 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204739 NZ_CP101233:3324872-3325090 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204739 WP_000588712.1 NZ_CP076190:2287238-2287363 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204739 NZ_CP101233:3324472-3324846 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References