Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2302775..2303750 Replicon chromosome
Accession NZ_CP076187
Organism Bacillus anthracis str. BF1

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM400_RS12065 Protein ID WP_002036394.1
Coordinates 2302775..2303512 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM400_RS12070 Protein ID WP_000588712.1
Coordinates 2303625..2303750 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM400_RS12045 (KM400_12025) 2298503..2299285 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM400_RS12050 (KM400_12030) 2299407..2301092 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
KM400_RS12055 (KM400_12035) 2301199..2301681 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM400_RS12060 (KM400_12040) 2301849..2302586 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM400_RS12065 (KM400_12045) 2302775..2303512 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM400_RS12070 (KM400_12050) 2303625..2303750 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM400_RS12075 (KM400_12055) 2303773..2304003 + 231 WP_011053163.1 stage II sporulation protein SB -
KM400_RS12080 (KM400_12060) 2304040..2304321 - 282 WP_001041555.1 hypothetical protein -
KM400_RS12085 (KM400_12065) 2304598..2304834 - 237 WP_001021688.1 hypothetical protein -
KM400_RS28725 2304971..2305096 + 126 WP_000694311.1 hypothetical protein -
KM400_RS12090 (KM400_12070) 2305173..2305349 + 177 WP_000808045.1 stage II sporulation protein SB -
KM400_RS12095 (KM400_12075) 2305493..2306962 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM400_RS12100 (KM400_12080) 2307526..2307996 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204737 WP_002036394.1 NZ_CP076187:2302775-2303512 [Bacillus anthracis str. BF1]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204737 NZ_CP101233:2533074-2533181 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204737 WP_000588712.1 NZ_CP076187:2303625-2303750 [Bacillus anthracis str. BF1]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204737 NZ_CP101233:c2533027-2532961 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References